In the digital era, supply chain security (SCS) is paramount for companies, governments, and consumers. Technological advancements, notably IoT and blockchain, enhance supply chain safety and transparency. Blockchain ensures data integrity and traceability, reducing fraud. IoT devices enable real-time monitoring for proactive risk management. Networked sensors provide asset data for preventive maintenance and route optimization. ML and AI algorithms detect security issues, while UAVs and self-driving vehicles enhance logistics. Automated last-mile delivery mitigates human risk. The chapter explores blockchain's role in SCS, addresses challenges, and discusses future advancements to bolster global resilience.