Bayesian calibration of a computational model of tissue expansion based on a porcine animal model

Han, Tianhong; Lee, Taeksang; Ledwon, Joanna K.; Vaca, Elbert E.; Turin, Sergey Y.; Kearney, Aaron M.; Gosain, Arun K.; Tepole, Adrián Buganza

doi:10.1016/j.actbio.2021.10.007

Cited by 17 publications

(13 citation statements)

References 64 publications

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“…The pattern of deformation (greater deformation at the apex compared with the rest of the expanded region) and the observation that growth was proportional to the total deformation aligns with our previous work on quantifying deformation and growth in tissue expansion. 5,7,25 The most interesting findings in the present work are that the TE model produced larger deformation than the ADM model as already mentioned, but also that the standard deviation in the histograms of deformation and growth are also higher in the TE compared with the ADM model. This means that tissue expansion without use of ADM produced a more uneven deformation compared with tissue expansion with use of ADM.…”

Section: Discussionsupporting

confidence: 81%

Acellular dermal matrix cover improves skin growth during tissue expansion by affecting distribution of mechanical forces

Ledwon

Applebaum

Progri

et al. 2023

Plastic &Amp; Reconstructive Surgery

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fficient skin growth during tissue expansion is critical for obtaining satisfactory outcomes from reconstructive operations. Despite many years of practice, tissue expansion still relies mostly on the surgeon's skills and expertise, and on the innate ability of the skin to grow in response to mechanical forces. 1 According to the American Society of Plastic Surgeons in 2018, 61% of two-stage breast reconstruction cases involving a tissue expander performed in the United States used a biologically derived acellular dermal matrix (ADM), 2 even though use of ADM or any other biological cover for the tissue expander has yet to be approved by the U.S. Food and Drug Administration for this specific purpose. Lack of requisite animal studies demonstratingBackground: Biological cover over tissue expander prostheses has been introduced to provide soft-tissue support for tissue expanders during breast reconstruction. However, its impact on mechanically induced skin growth remains unknown. This study investigates the hypothesis that covering the tissue expander with acellular dermal matrix (ADM) affects mechanotransduction without compromising the efficacy of tissue expansion. Methods: Tissue expansion, with and without use of ADM, was performed on a porcine model. The tissue expanders were inflated twice with 45 mL of saline, and the full-thickness skin biopsy specimens were harvested from expanded and control unexpanded skin 1 week and 8 weeks after the final inflation. Histologic evaluation, immunohistochemistry staining, and gene expression analysis were performed. Skin growth and total deformation were evaluated using isogeometric analysis. Results: The authors' results demonstrate that use of ADM as a biological cover during tissue expansion does not impede mechanotransduction that leads to skin growth and blood vessel formation. Isogeometric analysis revealed similar total deformation and growth of expanded skin with and without a biological cover, confirming that its use does not inhibit mechanically induced skin growth. In addition, the authors found that use of an ADM cover results in more uniform distribution of mechanical forces applied by the tissue expander. Conclusions: These results suggest that ADM improves mechanically induced skin growth during tissue expansion by facilitating a more uniform distribution of mechanical forces applied by the tissue expander. Therefore, the use of a biological cover has potential to improve outcomes in tissue expansion-based reconstruction.

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Section: Discussionsupporting

confidence: 81%

Acellular dermal matrix cover improves skin growth during tissue expansion by affecting distribution of mechanical forces

Ledwon

Applebaum

Progri

et al. 2023

Plastic &Amp; Reconstructive Surgery

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“…Some studies have used finite element analysis to model tissue expansion, providing a method to map the stress distribution of the skin during expansion. [33][34][35] Additionally, we observed strong inter-individual fluctuations of atmospheric oxygen influx. In our experiment, animal age, gender and skin humidity have been controlled.…”

Section: Discussionmentioning

confidence: 65%

“…However, an accurate stress profile of the expander has not been quantified. Some studies have used finite element analysis to model tissue expansion, providing a method to map the stress distribution of the skin during expansion 33–35 . Additionally, we observed strong inter‐individual fluctuations of atmospheric oxygen influx.…”

Section: Discussionmentioning

confidence: 70%

Dynamics of cutaneous atmospheric oxygen uptake in response to mechanical stretch revealed by optical fiber microsensor

Shan,

He,

Sun

et al. 2023

Experimental Dermatology

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Skin expands and regenerates in response to mechanical stretch. This important homeostasis process is critical for skin biology and can be exploited to generate extra skin for reconstructive surgery. Atmospheric oxygen uptake is important in skin homeostasis. However, whether and how cutaneous atmospheric oxygen uptake changes during mechanical stretch remains unclear, and relevant research tools to quantify oxygen flux are limited. Herein, we used the scanning micro‐optrode technique (SMOT), a non‐invasive self‐referencing optical fiber microsensor, to achieve real‐time measurement of cutaneous oxygen uptake from the atmosphere. An in vivo mechanical stretch‐induced skin expansion model was established, and an in vitro Flexcell Tension system was used to stretch epidermal cells. We found that oxygen influx of skin increased dramatically after stretching for 1 to 3 days and decreased to the non‐stretched level after 7 days. The enhanced oxygen influx of stretched skin was associated with increased epidermal basal cell proliferation and impaired epidermal barrier. In conclusion, mechanical stretch increases cutaneous oxygen uptake with spatial‐temporal characteristics, correlating with cell proliferation and barrier changes, suggesting a fundamental mechanistic role of oxygen uptake in the skin in response to mechanical stretch. Optical fiber microsensor‐based oxygen uptake detection provides a non‐invasive approach to understand skin homeostasis.

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“…In fact, this pipeline is also applicable to the problem of heterogeneous pure shear through replacing the analytical solution with a finite-element approach, see figure 4(ii). We and others have used this or similar approaches extensively for the purpose of identifying material parameters for soft tissues [66,67]. In short, we use a least-squares solver to minimize an objective function that penalizes the difference between our experimental force-displacement-or, equivalently-stress-stretch data and our analytically predicted data.…”

Section: (B) Homogeneous Pure Shearmentioning

confidence: 99%

An introduction to the Ogden model in biomechanics: benefits, implementation tools and limitations

Lohr

Sugerman

Kakaletsis

et al. 2022

Phil. Trans. R. Soc. A.

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Constitutive models are important to biomechanics for two key reasons. First, constitutive modelling is an essential component of characterizing tissues’ mechanical properties for informing theoretical and computational models of biomechanical systems. Second, constitutive models can be used as a theoretical framework for extracting and comparing key quantities of interest from material characterization experiments. Over the past five decades, the Ogden model has emerged as a popular constitutive model in soft tissue biomechanics with relevance to both informing theoretical and computational models and to comparing material characterization experiments. The goal of this short review is threefold. First, we will discuss the broad relevance of the Ogden model to soft tissue biomechanics and the general characteristics of soft tissues that are suitable for approximating with the Ogden model. Second, we will highlight exemplary uses of the Ogden model in brain tissue, blood clot and other tissues. Finally, we offer a tutorial on fitting the one-term Ogden model to pure shear experimental data via both an analytical approximation of homogeneous deformation and a finite-element model of the tissue domain. Overall, we anticipate that this short review will serve as a practical introduction to the use of the Ogden model in biomechanics. This article is part of the theme issue ‘The Ogden model of rubber mechanics: Fifty years of impact on nonlinear elasticity’.

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Bayesian calibration of a computational model of tissue expansion based on a porcine animal model

Cited by 17 publications

References 64 publications

Acellular dermal matrix cover improves skin growth during tissue expansion by affecting distribution of mechanical forces

Acellular dermal matrix cover improves skin growth during tissue expansion by affecting distribution of mechanical forces

Dynamics of cutaneous atmospheric oxygen uptake in response to mechanical stretch revealed by optical fiber microsensor

An introduction to the Ogden model in biomechanics: benefits, implementation tools and limitations

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