2020
DOI: 10.1103/physrevd.102.063513
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Bayesian comparison of the cosmic duality scenarios

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Cited by 12 publications
(10 citation statements)
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“…As CD8 + T cells express IL-2Rβγ and immunosuppressive Tregs constitutively express IL-2Rαβγ, these findings suggest that the latent cytokine may improve CD8 + /Treg ratios, which are prognostically favorable in many cancers 39 and correlate with clinical responses to an immune checkpoint blockade therapy in patients. 40 While other mechanisms of cytokine receptor subunit-biasing based on mutagenesis, 41,42 antibody complexation, 43 and de novo protein design 44 have been reported, here, we hypothesize that atypically high density of solvent-accessible lysine resides at the IL-2/IL-2Rα interface preferentially induces steric hindrance with the receptor subunit via appended polymer chains. 24 In addition to demonstrating rapid and efficient cytokine photoactivation, we also found that polymer photocages used here were highly stable under conditions simulating both aqueous storage and venous ambient light exposure.…”
Section: Discussionmentioning
confidence: 70%
“…As CD8 + T cells express IL-2Rβγ and immunosuppressive Tregs constitutively express IL-2Rαβγ, these findings suggest that the latent cytokine may improve CD8 + /Treg ratios, which are prognostically favorable in many cancers 39 and correlate with clinical responses to an immune checkpoint blockade therapy in patients. 40 While other mechanisms of cytokine receptor subunit-biasing based on mutagenesis, 41,42 antibody complexation, 43 and de novo protein design 44 have been reported, here, we hypothesize that atypically high density of solvent-accessible lysine resides at the IL-2/IL-2Rα interface preferentially induces steric hindrance with the receptor subunit via appended polymer chains. 24 In addition to demonstrating rapid and efficient cytokine photoactivation, we also found that polymer photocages used here were highly stable under conditions simulating both aqueous storage and venous ambient light exposure.…”
Section: Discussionmentioning
confidence: 70%
“…However, it is worth stressing that current analysis could not distinguish which η(z) function best describes the data (see details in Ref. [65]).…”
Section: Introductionmentioning
confidence: 88%
“…in the last decade . However, it is worth to stress that the current analysis cannot distinguish which η(z) function better describes the data (see [40]) for details.…”
Section: Introductionmentioning
confidence: 95%