While there is evidence for the existence of dark matter, its properties have yet to be discovered. Simultaneously, the nature of high-energy astrophysical neutrinos detected by IceCube remains unresolved. If dark matter and neutrinos are coupled to each other, they could exhibit a non-zero elastic scattering cross section. Such an interaction between an isotropic extragalactic neutrino flux and dark matter would be concentrated in the Galactic Centre, where the dark matter column density is the greatest. This scattering would attenuate the flux of high-energy neutrinos, which could be observed in the IceCube South Pole Neutrino Observatory. In this thesis, an unbinned likelihood analysis is performed to set sensitivities for the seven year medium energy starting event cascades dataset for a signal considering possible dark matterneutrino interaction scenarios. This signal would be observed as a suppression of the high-energy astrophysical neutrino flux in the direction of the Galactic Centre. It is shown that IceCube can set constraints on possible dark matter-neutrino interactions that are complementary to constraints set by large scale structure surveys and the cosmic microwave background. i I would like to thank my supervisor Aaron Vincent at Queen's and co-supervisor Carlos Argüelles at Harvard for their support and guidance during the course of this thesis. I have been extremely lucky to have great supervisors who patiently answer all my questions and provide invaluable advice. I would also like to thank Austin Schneider for his excellent insight with this analysis. I would like to acknowledge the support of NSERC, the IceCube collaboration, the Frontenac Cluster, and the Canadian Armed Forces in making this thesis possible. I would also like to thank all my family and friends for their support during this degree. I would especially like to thank Eric and Mikayla McMullen for editing this thesis and Simran Nerval for providing feedback for my thesis presentation. I would also like to thank the members of my thesis committee, Joe Bramante and Nahee Park for their comments and discussion during the thesis defence.