2021
DOI: 10.1101/2020.12.31.20249095
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Bayesian forecasting for intravenous tobramycin dosing in adults with Cystic Fibrosis using one versus two serum concentrations in a dosing interval

Abstract: BackgroundIntravenous tobramycin requires therapeutic drug monitoring (TDM) to ensure safety and efficacy when used for prolonged treatment, as in infective exacerbations of Cystic Fibrosis (CF). The 24 hour area under the concentration time curve (AUC24) is widely used to guide dosing, however there remains variability in practice around methods for its estimation.ObjectivesTo determine the potential for a sparse sampling strategy using a single post-infusion tobramycin concentration and Bayesian forecasting,… Show more

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“…We are currently performing comparative studies on this matter using BestDose (Laboratory of Applied Pharmacokinetics and Bioinformatics, USC) and Tucuxi (HEIG‐VD, Yverdon‐les‐Bains, Switzerland), a recently developed software based on the parametric approach 18 . For busulfan in children, the results in terms of predicted exposure and dosages were very similar, and the differences were not clinically relevant 19…”
Section: General Questions On Both Approachesmentioning
confidence: 99%
“…We are currently performing comparative studies on this matter using BestDose (Laboratory of Applied Pharmacokinetics and Bioinformatics, USC) and Tucuxi (HEIG‐VD, Yverdon‐les‐Bains, Switzerland), a recently developed software based on the parametric approach 18 . For busulfan in children, the results in terms of predicted exposure and dosages were very similar, and the differences were not clinically relevant 19…”
Section: General Questions On Both Approachesmentioning
confidence: 99%