Bayesian prediction for liver fibrosis staging: Combined use of elastography and serum fibrosis markers

Ichikawa, Tomoaki; Araki, Tsutomu; Matsuda, Masanori; Fujii, Hideki; Enomoto, Nobuyuki

doi:10.1002/hep.26144

Cited by 9 publications

(15 citation statements)

References 7 publications

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“…Another advantage of the Bayesian method, which was not investigated in this study, is that we can combine more than one test, as we do mentally while arriving at a clinical decision . The Bayesian method enables addition of the results of secondary tests, thus increasing the posterior probability of the results (fibrosis staging in this case).…”

Section: Discussionmentioning

confidence: 99%

“…However, a cutoff method for staging always involves a compromise between sensitivity and specificity. The Bayesian method is another method to stage liver fibrosis besides the cutoff method . The Bayesian method calculates posttest (post‐MRE) probability of each stage of fibrosis, that is, the confidence of staging for each stage, yielding the most likely stage of fibrosis as well as the confidence level.…”

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confidence: 99%

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Noninvasive hepatic fibrosis staging using mr elastography: The usefulness of the bayesian prediction method

Ichikawa

Enomoto

Matsuda

et al. 2016

Magnetic Resonance Imaging

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Section: Discussionmentioning

confidence: 99%

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confidence: 99%

Noninvasive hepatic fibrosis staging using mr elastography: The usefulness of the bayesian prediction method

Ichikawa

Enomoto

Matsuda

et al. 2016

Magnetic Resonance Imaging

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“…MR Elastography technique has also been further validated for assessing diffused liver diseases (46,47). Along with technical improvements, integrated liver multi-parametric imaging will likely improve the sensitivity and specificity for early stage liver fibrosis characterization (48)(49)(50)(51)(52), or a combination of MR readout and serum fibrosis markers and the use of decision trees, such as Bayesian prediction, will allow high validity for a diagnostic approach (53,54).…”

Section: Bdl Is a Well Established Model For Liver Fibrosis Researchmentioning

confidence: 99%

Black blood T1rho MR imaging may diagnose early stage liver fibrosis: a proof-of-principle study with rat biliary duct ligation model

Koon¹,

Zhang²,

Chen

et al. 2016

Quant. Imaging Med. Surg.

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Background: To explore black blood T1rho (T1ρ) liver imaging and investigate the earliest stage when biliary duct ligation (BDL) induced liver fibrosis can be diagnosed.Methods: MR was performed at 3 Tesla. A T1ρ prepared 2D fast spin echo (FSE) sequence with acquisition of four spin lock times (TSLs: 1, 10, 30, and 50 msec) and spin-lock frequency of 500 Hz was applied.Inherent black blood effect of FSE and double inversion recovery (DIR) achieved blood signal suppression, and 3 axial sections per liver were obtained. Male Sprague-Dawley rats were scanned at baseline (n=32), and on day-3 (n=13), day-5 (n=11), day-7 (n=10), day-10 (n=4) respectively after BDL. Hematoxylin-eosin (HE) and picrosirius red staining liver histology was obtained at these time points.Results: The physiological liver parenchyma T1ρ was 38.38±1.53 msec (range, 36.05-41.53 msec). Liver T1ρ value elevated progressively after BDL. On day-10 after BDL all experimental animals can be separated from normal liver based on T1ρ measurement with lowest value being 42.82 msec. Day-7 and day-10 liver resembled METAVIR stage-F1/F2 fibrosis, and fibrous area counted for 0.22%±0.13% and 0.38%±0.44% of liver parenchyma area, respectively. Conclusions:This study provides the first proof-of-principle that T1ρ might diagnose early stage liver fibrosis.

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“…Further, a prospective validation study that combines these methods would offer comfortable and low risk management of liver disease. 67,68 The current study had some limitations. First, we included no F0 case because of the minimal clinical requirement for performing a biopsy to evaluate fibrosis during early stages of liver disease.…”

Section: Discussionmentioning

confidence: 91%

Validity and Reliability of Magnetic Resonance Elastography for Staging Hepatic Fibrosis in Patients with Chronic Hepatitis B

et al. 2015

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Purpose: We evaluated the validity and reliability of magnetic resonance elastography (MRE) for staging hepatic fibrosis in patients with chronic hepatitis B.Methods: The study included 73 patients with chronic hepatitis B and confirmed stages of pathological fibrosis. Two radiologists measured liver stiffness using MRE in all cases. We compared the area under the receiver operating characteristic (ROC) curve (Az) for distinguishing stages of fibrosis compared with MRE liver stiffness measurements and serum fibrosis markers. We used intraclass correlation coefficients to analyze interobserver agreement for measurements of liver stiffness and 2 one-sided t-tests to test the equivalence of the measurements by the 2 observers.Results: ROC analyses revealed the significantly superior discrimination abilities of MRE for liver fibrosis staging (Az = 0.945 to 0.978 [Observer 1] and 0.936 to 0.967 [Observer 2]) to those of serum fibrosis markers (0.491 to 0.742) for both observers (P < 0.0004). The intraclass correlation coefficient between the 2 observers was excellent (µ = 0.971), and the measurements of liver stiffness by the 2 observers were statistically equivalent within a 0.1-kPa difference (P = 0.0157) Conclusion: MRE is a valid and reliable technique for discriminating the stage of hepatic fibrosis in patients with chronic hepatitis B.

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Bayesian prediction for liver fibrosis staging: Combined use of elastography and serum fibrosis markers

Cited by 9 publications

References 7 publications

Noninvasive hepatic fibrosis staging using mr elastography: The usefulness of the bayesian prediction method

Noninvasive hepatic fibrosis staging using mr elastography: The usefulness of the bayesian prediction method

Black blood T1rho MR imaging may diagnose early stage liver fibrosis: a proof-of-principle study with rat biliary duct ligation model

Validity and Reliability of Magnetic Resonance Elastography for Staging Hepatic Fibrosis in Patients with Chronic Hepatitis B

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