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Bateman, RM; Sharpe,; Cg, Ellis

doi:10.1186/cc1940

Cited by 3 publications

(2 citation statements)

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“…The MCTSI, developed by Mortele et al, 31 is recognized for its closer association with patient prognosis, as elevated MCTSI scores reflect greater pancreatic necrosis and more pronounced pancreatic and peripancreatic inflammation, creating an environment conducive to pathogen proliferation 32 . In addition, patients with elevated MCTSI scores require prolonged fasting and intravenous nutritional support, potentially leading to intestinal mucosal dysfunction and increased susceptibility to secondary infection due to bacterial translocation in the gut 33 . Our findings also confirm that the MCTSI score is an independent risk factor for the development of IPN, which is consistent with previous studies 34,35 …”

Section: Discussionmentioning

confidence: 99%

Nomogram for the prediction of infected pancreatic necrosis in moderately severe and severe acute pancreatitis

Song,

Chen,

Zhao

et al. 2024

J of Digest Diseases

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ObjectivesAs a serious complication of moderately severe acute pancreatitis (MSAP) and severe acute pancreatitis (SAP), infected pancreatic necrosis (IPN) can lead to a prolonged course of interventional therapy. Most predictive models designed to identify such patients are complex or lack validation. The aim of this study was to develop a predictive model for the early detection of IPN in MSAP and SAP.MethodsA total of 594 patients with MSAP or SAP were included in the study. To reduce dimensionality, least absolute shrinkage and selection operator regression analysis was used to screen potential predictive variables, a nomogram was then constructed using logistic regression analysis. The receiver operating characteristic (ROC) curve, calibration curve, and decision curve analysis (DCA) were used to evaluate the discrimination, accuracy, and clinical efficacy of the model. External data were also obtained to further validate the constructed model.ResultsThere were 476, 118, and 82 patients in the training, internal validation, and external validation cohorts, respectively. Platelet count, hematocrit, albumin/globulin, severity of acute pancreatitis, and modified computed tomography severity index score were independent factors for predicting IPN in MSAP and SAP. The area under the ROC curves were 0.923, 0.940, and 0.817, respectively, in the three groups. There was a good consistency between the actual probabilities and the predicted probabilities. DCA revealed excellent clinical utility.ConclusionThe constructed nomogram is a simple and feasible model that has good clinical predictive value and efficacy in clinical decision‐making for IPN in MSAP and SAP.

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Section: Discussionmentioning

confidence: 99%

Nomogram for the prediction of infected pancreatic necrosis in moderately severe and severe acute pancreatitis

Song,

Chen,

Zhao

et al. 2024

J of Digest Diseases

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“…The D‐Dimer concentration has been proposed as a useful predictor of fatal outcomes, 32 however, we did not observe a statistically significant difference in the plasma concentration of D‐Dimer between survivors and non‐survivors. This could be due to differential endothelial dysfunction states, and may be related to both inflammatory and chronic diseases, because D‐Dimer can be modified due to coagulopathy and endothelial activation 33 …”

Section: Discussionmentioning

confidence: 99%

Potential biomarkers for fatal outcome prognosis in a cohort of hospitalized COVID‐19 patients with pre‐existing comorbidities

Madera‐Sandoval,

Cérbulo‐Vázquez,

Arriaga‐Pizano

et al. 2023

Clinical Translational Sci

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The difficulty in predicting fatal outcomes in COVID‐19 patients impacts the general morbidity and mortality due to SARSCoV2 infection, as it wears out the hospital services that care for these patients. Unfortunately, in several of the candidates for prognostic biomarkers proposed, the predictive power is compromised when patients have pre‐existing co‐morbidities. A cohort of one hundred and forty‐seven patients hospitalized for severe COVID‐19 was included in a descriptive, observational, single‐center, and prospective study. Patients were recruited during the first COVID‐19 pandemic wave (April‐Nov, 2020). Data were collected from the clinical history while immunophenotyping by multiparameter flow cytometry analysis allowed us to assess the expression of surface markers on peripheral leukocytes. Patients were grouped according to the outcome in survivor or non‐survivor. The prognostic value of leukocytes, cytokines or HLA‐DR, CD39, and CD73 was calculated. Hypertension and chronic renal failure but not obesity and diabetes were conditions more frequent among the decease group. Mixed hypercytokinemia, including inflammatory (IL‐6) and anti‐inflammatory (IL‐10) cytokines, was more evident in deceased patients. In the decease group, lymphopenia with a higher Neutrophil‐Lymphocyte Ratio value was present. HLA‐DR expression and the percentage of CD39+ cells were higher than non‐COVID‐19 patients but remained similar despite the outcome. ROC analysis and cut‐off value of Neutrophil‐Lymphocyte Ratio (69.6%, 9.4), percentage Neutrophil‐Lymphocyte Ratio (71.1%, 13.6), IL‐6 (79.7%, 135.2 pg/mL). The expression of HLA‐DR, CD39, and CD73, as many serum cytokines (other than IL‐6) and chemokines levels do not show prognostic potential compared to Neutrophil‐Lymphocyte Ratio and percentage Neutrophil‐Lymphocyte Ratio values.

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Avoiding Arterial Hypotension in Preterm Neonates (AHIP)—A Single Center Randomised Controlled Study Investigating Simultaneous Near Infrared Spectroscopy Measurements of Cerebral and Peripheral Regional Tissue Oxygenation and Dedicated Interventions

et al. 2018

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IntroductionUp to 50% of preterm infants admitted to intensive care units require cardiocirculatory support. The aim of the present study was to assess whether simultaneous monitoring of cerebral tissue oxygenation index (cTOI) and peripheral tissue oxygenation index (pTOI) using near-infrared spectroscopy (NIRS) in combination with dedicated intervention guidelines may help avoiding arterial hypotension and catecholamine administration in preterm neonates.Study designPreterm neonates <37 weeks of gestation were included in a single center randomized controlled study. Blood pressure was measured non-invasively or invasively. In the NIRS group, simultaneous cTOI and pTOI monitoring was used starting within 6 h after birth for 24 h to calculate changes in cTOI/pTOI ratio over time. Depending on these changes, interventions including echocardiography, administration of volume or patent ductus arteriosus treatment were performed. In the control group, only routine monitoring and treatment were performed and NIRS signals were not visible. The primary outcome was burden of hypotension within 48 h after initiation of NIRS monitoring.Results49 preterm neonates were included in each group: NIRS group 33.1 (32.0–34.0) (median: 25–75 centile) weeks of gestation and control group 33.4 (32.3–34.3) weeks of gestation. In the NIRS group, echocardiography was performed in 17 preterm neonates due to NIRS measurements, whereby six neonates received further treatment. Percentage of neonates with any hypotensive episode during the 48-h observational period was 32.6% in the NIRS group and 44.9% in the control group (p = 0.214). Burden of hypotension (i.e., %mmHg of mean arterial pressure < gestational age) was 0.0 (0.0–2.1) mmHg h in the NIRS group and 0.4 (0.0–3.3) mmHg h in the control group (p = 0.313), with observed burden of hypotension being low in both groups. No severe adverse reactions were observed.ConclusionIn preterm neonates using simultaneous peripheral and cerebral NIRS measurements for early detection of centralization followed by predefined interventions led to a non-significant reduction in burden of arterial hypotension.Clinical Trial Registration, identifier: NCT01910467.

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Cited by 3 publications

References 2 publications

Nomogram for the prediction of infected pancreatic necrosis in moderately severe and severe acute pancreatitis

Nomogram for the prediction of infected pancreatic necrosis in moderately severe and severe acute pancreatitis

Potential biomarkers for fatal outcome prognosis in a cohort of hospitalized COVID‐19 patients with pre‐existing comorbidities

Avoiding Arterial Hypotension in Preterm Neonates (AHIP)—A Single Center Randomised Controlled Study Investigating Simultaneous Near Infrared Spectroscopy Measurements of Cerebral and Peripheral Regional Tissue Oxygenation and Dedicated Interventions

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