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Choi, Choong Hyeok; Cha, Yoon-Jung; An, Chun-San; Kim, Kyung Jong; Kim, Kweon-Cheon; Moon, Sung-Pyo; Lee, Zang Hee; Min, Young Don

doi:10.1186/1475-2867-4-6

Cited by 48 publications

(13 citation statements)

References 31 publications

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“…The plates were held for 5 min at room temperature with shaking in order to completely dissolve formazan. The absorbance of the MTT formazan was determined at 540 nm using a UV-spectrophotometric plate reader ( Choi et al ., 2004 ).…”

Section: Methodsmentioning

confidence: 99%

Protective Effect of Liriodendrin Isolated from Kalopanax pictus against Gastric Injury

Sohn

Hwang

Lee

et al. 2015

Biomolecules & Therapeutics

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In this study, we investigated the inhibitory activities on gastritis and gastric ulcer using liriodendrin which is a constituent isolated from Kalopanax pictus. To elucidate its abilities to prevent gastric injury, we measured the quantity of prostaglandin E2 (PGE2) as the protective factor, and we assessed inhibition of activities related to excessive gastric acid be notorious for aggressive factor and inhibition of Helicobacter pylori (H. pylori) colonization known as a cause of chronic gastritis, gastric ulcer, and gastric cancer. Liriodendrin exhibited higher PGE2 level than rebamipide used as a positive control group at the dose of 500 μM. It was also exhibited acid-neutralizing capacity (10.3%) and H+/K+-ATPase inhibition of 42.6% (500 μM). In pylorus-ligated rats, liriodendrin showed lower volume of gastric juice (4.38 ± 2.14 ml), slightly higher pH (1.53 ± 0.41), and smaller total acid output (0.47 ± 0.3 mEq/4 hrs) than the control group. Furthermore liriodendrin inhibited colonization of H. pylori effectively. In vivo test, liriodendrin significantly inhibited both of HCl/EtOH-induced gastritis (46.9 %) and indomethacin-induced gastric ulcer (46.1%). From these results, we suggest that liriodendrin could be utilized for the treatment and/or protection of gastritis and gastric ulcer.

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Section: Methodsmentioning

confidence: 99%

Protective Effect of Liriodendrin Isolated from Kalopanax pictus against Gastric Injury

Sohn

Hwang

Lee

et al. 2015

Biomolecules & Therapeutics

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“…The absorbance of the MTT formazan was determined at 540 nm using a UV-spectrophotometric plate reader (Choi et al , 2004).…”

Section: Methodsmentioning

confidence: 99%

Inhibitory Effects of 4-Guanidinobutyric Acid against Gastric Lesions

Hwang

Jeong

2012

Biomolecules and Therapeutics

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This study examined the inhibitory effects of 4-guanidinobutyric acid (4GBA), an alkaloid, against gastric lesions by assessing the inhibition of Helicobacter pylori (H. pylori) and gastric cancer cells. Acute and chronic gastritis were also observed using HCl/ethanol (EtOH) and indomethacin-induced gastric lesion models, respectively. 4GBA inhibited the growth of H. pylori in a dose dependent manner, and showed acid-neutralizing capacity. In the pylorus ligated rats, 4GBA decreased the volume of gastric secretion and gastric acid output slightly, and increased the pH. 4GBA at a dose of 100 mg/kg reduced the size of HCl/EtOH-induced gastric lesions (70.8%) and indomethacin-induced gastric lesions (38.8%). The antigastritic action of 4GBA might be associated with the acid-neutralizing capacity, anti-H. pylori action, and decreased volume of gastric secretion. These results suggest that 4GBA might be useful in the treatment and/or protection of gastritis.

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“…Thus the application of the drug is restricted to a relatively narrow class of tumors and the efforts were focused on the design of new platinum compounds with broader spectrum of antitumor activity and improved pharmacological properties with respect to toxicity and resistance. Several complexes structurally related to cis -platin, such as oxaliplatin and carboplatin, nedaplatin (Japan), lobaplatin (China), heptaplatin (South Korea) [ 5 , 13 , 14 ], are currently in clinical trials and use, but till now they have not demonstrated significant advantages over cis -platin. It seems possible that the complex structural analogs of cis -platin designed on the basis of structure-activity relationships [ 15 ] could scarcely offer serious advantages over the existing drugs.…”

Section: Introductionmentioning

confidence: 99%

Synthesis, Structural Characterization, and Cytotoxic Activity of Novel Paramagnetic Platinum Hematoporphyrin IX Complexes: Potent Antitumor Agents

et al. 2007

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Three novel stable Pt(III) complexes with distorted octahedral structure and (dz2)1 ground state have been obtained in the course of Pt(II)-hematoporphyrin IX ((7,12-bis(1-hydroxyethyl)-3,8,13,17-tetramethyl-21H-23H-porphyn-2,18-dipropionic acid), Hp) interaction in alkaline aqueous medium and aerobic conditions. A redox interaction also takes place together with the complexation process leading to the formation of Pt(III) species and organic radicals. The processes in the reaction system and the structure of the complexes formed cis-[Pt(III)false(NH3false)2(Hp−3H)false(H2Ofalse)2]⋅H2O 1, [Pt(III)(Hp−3H)false(H2Ofalse)2]⋅H2O 2, and [Pt((O,O)Hp−2H)Clfalse(H2Ofalse)3] 3, were studied by UV-Vis, IR, EPR and XPS spectra, thermal (TGS, DSC), potentiometric and magnetic methods. The newly synthesized complexes show promising cytotoxic activity comparable with that of cis-platin in in vitro tests against a panel of human leukemia cell lines. The observed cytotoxicity of the complex 2 against SKW-3 cells (KE-37 derivative) is due to induction of cell death through apoptosis.

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Abstract: Background: Heptaplatin is a new platinum derivative with anticancer activity against various cancer cell lines, including cisplatin-resistant cancer cell lines (Cancer Chemother Pharmacol 1995; 35: 441).

Cited by 48 publications

References 31 publications

Protective Effect of Liriodendrin Isolated from Kalopanax pictus against Gastric Injury

Protective Effect of Liriodendrin Isolated from Kalopanax pictus against Gastric Injury

Inhibitory Effects of 4-Guanidinobutyric Acid against Gastric Lesions

Synthesis, Structural Characterization, and Cytotoxic Activity of Novel Paramagnetic Platinum Hematoporphyrin IX Complexes: Potent Antitumor Agents

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