BBOX1-AS1: A novel oncogenic long non-coding RNA in human cancers

Zhang, Renfang; Gao, Xiaohui; Gu, Xinyu

doi:10.1016/j.prp.2023.154810

Cited by 1 publication

(1 citation statement)

References 66 publications

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“…In terms of mechanism, BBOX1-AS1 predominantly functions as a ceRNA, exerting a negative regulatory effect on miRNA. This interference impacts the expression of downstream molecules, resulting in alterations in proliferation, invasion, epithelial-mesenchymal transition (EMT), as well as apoptosis (Zhang et al 2023 ). It has been reported that cytoplasmic TRPM2-AS can act as a promoter of cancer in GC by competitively binding to miRNAs (Huang et al 2019 ).This suggests that the lncRNA TRPM2-AS is capable of facilitating the progression of GC and enhancing its resistance to radiotherapy (Xiao et al 2020 ).…”

Section: Discussionmentioning

confidence: 99%

Genome-wide investigation of lncRNAs revealed their tight association with gastric cancer

Liu,

Ma,

Han

et al. 2024

J Cancer Res Clin Oncol

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Background Gastric cancer (GC) is a significant health issue globally, ranking as the fifth most common cancer with over 10,000 new cases reported annually. Long non-coding RNA (lncRNA) has emerged as a critical player in cellular functions, influencing GC's development, growth, metastasis, and prognosis. However, our understanding of lncRNA's role in the pathogenesis of GC remains limited. Therefore, it is particularly important to explore the relationship between lncRNA and gastric cancer. Methods we conducted a comprehensive analysis of RNA sequencing data from the GEO database and stomach adenocarcinoma (STAD) data from the TCGA database to identify lncRNAs that exhibit altered expression levels in GC and the mechanisms underlying lncRNA-mediated transcription and post-transcriptional regulation were explored. Results This study uncovered 94 lncRNAs with differential expression and, through co-expression analysis, linked these to 1508 differentially expressed genes (DEGs). GO functional enrichment analysis highlighted that these DEGs are involved in critical pathways, such as cell adhesion and the positive regulation of cell migration. By establishing a lncRNA-miRNA-mRNA regulatory network, we found that the ceRNA mechanism, particularly involving RP11-357H14.17 and CTD-2377D24.4, could play a role in GC progression. Experimental validation of selected differentially expressed lncRNAs and mRNAs (including RP11-357H14.17-CLDN1, BBOX1, TRPM2-AS, CLDN1, PLAU, HOXB7) confirmed the RNA-seq results. Conclusions Overall, our findings highlight the critical role of the lncRNA-mRNA regulatory network in the development and progression of GC, offering potential biomarkers for diagnosis and targets for innovative treatment strategies.

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Section: Discussionmentioning

confidence: 99%