BCG-Ulkus

Abstract

Following BCG vaccination, local or systemic complications may occur. A 19-year-old female patient with negative tuberculin skin test developed a blister evolving over two weeks into an ulcer in a vaccination site on the left hip. Ulcerations following BCG vaccination are rare and show a tendency to chronicity. The treatment recommendations are controversial and range from non-specific topical treatment to systemic tuberculostatic therapy. In this case, the ulcer cleared rapidly after topical treatment with INH powder.

Immunogenicity and reactogenicity after booster dose with AZD1222 via intradermal route among adult who had received CoronaVac

“…This study reported local reactogenicity including erythema, blister, and pruritus after ID AZD1222 booster vaccine which is similar to previous report on rabies inactivated vaccine that more erythema and pruritus were reported from ID than conventional IM administration [28]. Also blister formation was reported after BCG vaccination that evolved over two weeks into an ulcer at injection site [29]. ID influenza vaccine study reported significant higher local adverse events particularly erythema and swelling, and also more common of fever and chills which is different from this study that fever was more common in IM vaccination [9].…”

“…29 (29) 9 (9) 7 ( 7) Anti-S-RBD: anti Spike receptor binding domain, BAU: Binding-antibody unit, GM: Geometric mean, ID: intradermal, IM: intramuscular, sVNT-delta: Surrogate virus neutralization test against delta strain, sVNT-WT: Surrogate virus neutralization test against wild type † Anti-S-RBD IgG 506 BAU/ml correlated with 80% vaccine efficacy as reported by Feng, et al [17].…”

“…Median (IQR) of RBD-specific memory B cell spots at day 0 was 2 (0-10), increased to 18 (14-36) at day 28, and declined to 6 (4-20) SFU/10 6 PBMCs at day 90. Compared with IM study of 4 (0-16) at day 0, 26 (16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30)(31)(32) at day 28, and 8 (4-16) SFU/10 6 PBMCs at day 90.…”