1999
DOI: 10.1038/sj.onc.1202339
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Bcl-2 interferes with the execution phase, but not upstream events, in glucocorticoid-induced leukemia apoptosis

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Cited by 48 publications
(57 citation statements)
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“…28,29 The anti-apoptotic Bcl-2 was able to protect against apoptosis, but not against the anti-proliferative responses induced by GC. 30 Furthermore, inhibition of the anti-apoptotic Bcl-xL sensitized T-ALL cells to Dex-induced apoptosis. 31 Several pieces of our data point to the differential regulation of Bak and Bax in Dex-induced cell death in ALL cells.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…28,29 The anti-apoptotic Bcl-2 was able to protect against apoptosis, but not against the anti-proliferative responses induced by GC. 30 Furthermore, inhibition of the anti-apoptotic Bcl-xL sensitized T-ALL cells to Dex-induced apoptosis. 31 Several pieces of our data point to the differential regulation of Bak and Bax in Dex-induced cell death in ALL cells.…”
Section: Discussionmentioning
confidence: 99%
“…There are conflicting results concerning the exact role of caspases in GCinduced cell death. Some studies have indicated that inhibition of caspases protects against GC-induced apoptosis, 15,17,30,51,52 whereas other studies have shown opposite results. 16,53 In the present analysis, pan-caspase inhibition by zVAD-fmk clearly showed that Bak and Bax activation, mitochondrial depolarization and cell death induced by Dex could not be rescued.…”
Section: © F E R R a T A S T O R T I F O U N D A T I O Nmentioning
confidence: 99%
“…Inhibition of caspase 8 in human ALL cell lines did not prevent the cells from undergoing apoptosis (Geley et al 1997, Planey et al 2003 and this may indicate that the extrinsic pathway is not necessary for Gc-mediated apoptosis. Studies in human ALL cell lines showed that members of the anti-apoptotic Bcl-2 protein family were able to diminish Gc-mediated apoptosis in human ALL cell lines when overexpressed (Brunet et al 1998, Hartmann et al 1999. It has become evident that Gc-mediated apoptosis includes the upregulation of pro-apoptotic (Han et al 2001 and/or downregulation of anti-apoptotic genes (Chauhan et al 2002, Casale et al 2003 and this would therefore suggest that altering the expression levels of proteins involved in the Bcl-2 rheostat provides a mechanism for explaining Gc-mediated apoptosis .…”
Section: Resistance To Gc-induced Apoptosis In Lymphoblastic Leukaemiamentioning
confidence: 99%
“…The acute leukaemic T-lymphocyte cell line CCRF-CEM (ATCC, Manassas, VA, USA) and the CCRF-CEM-C7H2-10E1 cell line (kindly provided by Dr Kofler) (Hartmann et al, 1999) that is stably transfected with bcl-2 c-DNA were grown in RPMI 1640 medium (Gibco, Grand Island, NY, USA), supplemented with 10% foetal calf serum and 0.1 mg/ml gentamicin.…”
Section: Cell Culturementioning
confidence: 99%