Bcl-2 Upregulation Induced by miR-21 Via a Direct Interaction Is Associated with Apoptosis and Chemoresistance in MIA PaCa-2 Pancreatic Cancer Cells

MicroRNA-30a Sensitizes Tumor Cells to cis-Platinum via Suppressing Beclin 1-mediated Autophagy

“…For example, miR-34a directly affects cell chemosensitivity in Ewing's sarcoma (19) and breast cancer cells (20). miR-21 plays a role in chemosensitivity in bladder (21) and pancreatic cancer (22), and the expression of miR-140 is associated with chemosensitivity in osteosarcoma tumor xenografts (23). Furthermore, there is increasing evidence that miRNAs play a role in regulating cellular autophagy processes (24 -27).…”

Molecular and Genetic Bases of Pancreatic Cancer

“…Opposite trends were found in the cells transfected with miR--21 inhibitor [60]. Furthermore expression of the proapoptotic Bax gene in tumor samples from patients with PDAC is a strong indicator of a longer survival and overexpression of Bax may sensitize pancreatic cancer cells to 5--FU and gemcitabine [61].…”

Prognostic Factors after Curative Resection of Pancreatic Ductal Adenocarcinoma: a Retrospective Study

“…Expression of Bcl-2 in tumour cells has been noted as independent favourable prognostic factor and unfavourable predictive factor [14,[36][37][38]. Resistance to chemotherapyinduced apoptosis is associated with over-expression of Bcl-2 in pancreatic cancer [16,17]. A positive correlation has been found between the Bcl-2 expression and tumour invasion and development of metastases [16,38].…”

“…As a result, several factors have been identified that convincingly correlate with a progression of the carcinoma, resistance to chemo-and radiotherapy and survival rate of patients. However, contradictory findings have been published regarding several parameters [6,14,17]. The aim of this study was to acquire comprehensive data of characteristic features of pancreatic carcinoma in the Latvian population, frequency of the known unfavourable prognostic factors, the extent of the immunohistochemical expression of several biologic markers and the impact of all the acquired parameters on the survival rate of the patients.…”

“…Studies of several other markers have yielded contradictory results. These markers include tumour suppressor protein p53, mesenchymal cell intermediate filament vimentin, apoptosis regulator protein Bcl-2 as well as CD44 -cell surface glycoprotein, which is involved in cell adhesion, migration, proliferation and apoptosis [14,[16][17][18][19][20]. Thus, the aim of our study was to determine frequency and extent of expression of biological markers (Ki-67, p53, Bcl-2, vimentin, CD44) in relation to survival of patients after potentially radical surgical treatment of pancreatic carcinoma.…”