2023
DOI: 10.1038/s41418-023-01158-5
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BCL-G: 20 years of research on a non-typical protein from the BCL-2 family

Abstract: Proteins from the BCL-2 family control cell survival and apoptosis in health and disease, and regulate apoptosis-unrelated cellular processes. BCL-Gonad (BCL-G, also known as BCL2-like 14) is a non-typical protein of the family as its long isoform (BCL-GL) consists of BH2 and BH3 domains without the BH1 motif. BCL-G is predominantly expressed in normal testes and different organs of the gastrointestinal tract. The complexity of regulatory mechanisms of BCL-G expression and post-translational modifications sugg… Show more

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Cited by 5 publications
(1 citation statement)
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“…62 BCL-Gonad (BCL-G) is a unique and conserved member of the BCL-2 family and initially considered as a pro-apoptotic gene in humans. 63 In healthy gut tissue, both human BCL-G splice variants (BCL-GL, long; BCL-GS short) were found to be over-expressed in IECs. Compared with the non-IBD individuals, increased tissue expressions of Th1 cytokines (IFN-γ and TNF-α) could strongly suppress the BCL-GS expression, which differentially regulated the inflammatory chemokines (CCL5 and CCL20) and thereby might drive the pathophysiology of IBD (Figure 4C).…”
Section: As and Innate Immunementioning
confidence: 98%
“…62 BCL-Gonad (BCL-G) is a unique and conserved member of the BCL-2 family and initially considered as a pro-apoptotic gene in humans. 63 In healthy gut tissue, both human BCL-G splice variants (BCL-GL, long; BCL-GS short) were found to be over-expressed in IECs. Compared with the non-IBD individuals, increased tissue expressions of Th1 cytokines (IFN-γ and TNF-α) could strongly suppress the BCL-GS expression, which differentially regulated the inflammatory chemokines (CCL5 and CCL20) and thereby might drive the pathophysiology of IBD (Figure 4C).…”
Section: As and Innate Immunementioning
confidence: 98%