BCL10 mutations are irrelevant to its aberrant nuclear localization in nasal NK/T-cell lymphoma

Shen, Liangliang; Liang, Anna C.; Au, Wing Y.; Lu, Liwei; Chen, Y W; Wong, KY; Tang, Johnny; Chan, Kwok–Wah; Beh, Swan-Lip; Kwong, Yok–Lam; Liang, Raymond; Srivastava, Gopesh

doi:10.1038/sj.leu.2403128

Cited by 5 publications

(3 citation statements)

References 8 publications

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“…7E, Bcl10 with the Ser 218 / Ser 231 double mutation or with the C-terminal deletion exhibited high affinity for Bcl3. The latter finding might support the previous observation that C-terminally truncated Bcl10 exhibits nuclear distribution (30).…”

Section: Up-regulation Of Bcl10 By Tnf␣-induced Nf-b Activation-tnf␣supporting

confidence: 82%

“…A previous study reported that Bcl10 with a truncated C terminus shows nuclear distribution in NK/T cells (30), suggesting the Bcl10 C-terminal as a candidate region for Akt1 targeting. To investigate this speculation, wild-type and mutant Bcl10 proteins harboring the C-terminal 27-amino acid deletion were constructed and cloned into a His-tagged expression vector.…”

Section: Up-regulation Of Bcl10 By Tnf␣-induced Nf-b Activation-tnf␣mentioning

confidence: 99%

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A Pathway for Tumor Necrosis Factor-α-induced Bcl10 Nuclear Translocation

Yeh¹,

Kuo²,

Yeh³

et al. 2006

Journal of Biological Chemistry

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Bcl10 overexpression and nuclear translocation were originally identified in mucosa-associated lymphoid tissue lymphoma with t(1;14)(p32;q32) chromosome translocation. DNA amplification of Bcl10 was also found in other solid tumors. We have recently shown that nuclear translocation of Bcl10 is a specific molecular determinant of Helicobacter pylori-independent mucosa-associated lymphoid tissue lymphoma (

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Section: Up-regulation Of Bcl10 By Tnf␣-induced Nf-b Activation-tnf␣supporting

confidence: 82%

Section: Up-regulation Of Bcl10 By Tnf␣-induced Nf-b Activation-tnf␣mentioning

confidence: 99%

A Pathway for Tumor Necrosis Factor-α-induced Bcl10 Nuclear Translocation

Yeh¹,

Kuo²,

Yeh³

et al. 2006

Journal of Biological Chemistry

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“…Many different clonal cytogenetic and genetic abnormalities have been described in this lymphoma but they are usually non‐specific (Siu et al , 1999, 2000, 2002a,b; Shen et al , 2002, 2003; Iqbal et al , 2009). There are suggestions that some tumour suppressor genes are involved and are possibly important in the pathogenesis.…”

Section: Pathologymentioning

confidence: 99%

Advances in the management and monitoring of extranodal NK/T‐cell lymphoma, nasal type

Liang

2009

Br J Haematol

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Summary Extranodal natural killer (NK)/T‐cell lymphoma, nasal type, has a unique geographic distribution. Its pathology is characterized by marked angio‐invasion and tissue necrosis. A typical NK‐cell phenotype is usually present: CD2+, CD3 epsilon+, CD56+, cytotoxic molecules+ and Epstein–Barr virus (EBV)+. Magnetic Resonance Imaging helps to clearly define the local involvement. Positron Emission Tomography helps to demonstrate system spread. Various prognostic variables (International Prognostic Index or the Korean Prognostic Index) should be documented. This may include quantification of plasma EBV DNA. For localized nasal disease, radiotherapy is important, although chemotherapy is often added. Sustainable remission is observed in over half of these patients. For extra‐nasal or disseminated disease, systemic chemotherapy becomes the mainstay and the prognosis is usually poor. Doxorubicin‐containing regimens are not entirely satisfactory and l‐asparaginase containing regimens are being investigated. Patients with poor prognostic features may be considered for an early autologous haematopoietic stem cell transplant. Allogenetic transplantation is efficacious but is associated with high transplant‐related mortality.

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Nasal T/NK-Cell Lymphoma

Liang¹

2006

The Lymphomas

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BCL10 mutations are irrelevant to its aberrant nuclear localization in nasal NK/T-cell lymphoma

Cited by 5 publications

References 8 publications

A Pathway for Tumor Necrosis Factor-α-induced Bcl10 Nuclear Translocation

A Pathway for Tumor Necrosis Factor-α-induced Bcl10 Nuclear Translocation

Advances in the management and monitoring of extranodal NK/T‐cell lymphoma, nasal type

Nasal T/NK-Cell Lymphoma

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