Bcr‐abl positive blast crisis of chronic myeloid leukemia emerging in a case of metastatic colorectal cancer 3 months after completion of an 8‐month course of cetuximab and irinotecan

Chronic myeloid leukemia following the treatment of rectal adenocarcinoma

“…While progression time to leukemia was 11 months after the treatment with irinotecan and cetuximab, the time was 18 months after capecitabine and oxaliplatin. In this patient, hematological and molecular responses were obtained from imatinib mesylate as our patient [7]. Chronic phase Ph-positive CML was detected in another patient with colon adenocarcinoma treated with cisplatin and 5-fluorouracil [8].…”

“…In the literature, there are only two reports on CML developing after the treatment of colorectal carcinoma [7,8]. In one of these patients, Ph-positive blastic phase CML occurred after treatment with irinotecan and cetuximab.…”

“…In the literature, patients with CML following treatments of solid tumors had also received various other agents such as cisplatin, bleomycin, cetuximab, and 5-fluorouracil. The time range from initial diagnosis of the primary malignancy to CML was about 1-16 years in various reports [5,7,8,[10][11][12]15]. The risk of treatment-related CML after chemotherapy was estimated as 2.7-fold in one report [16].…”

“…Solid tumors such as thyroid, skin, lung, and breast cancers may occur in 3% of the patients with CML [2][3][4][5][6]. Gastrointestinal system malignancies such as colon, rectum, liver, and esophagus have been very rarely reported in CML [6][7][8][9][10][11]. Here we report a Ph-positive CML diagnosed in a patient who had been treated for rectal adenocarcinoma.…”

Chronic Myeloid Leukemia After Chemoradiotherapy in a Patient with Non-Small Cell Lung Cancer

“…The time range from initial diagnosis of the primary malignancy to tr-CML was about 1 -16 years in various reports. [6][7][8][9][10] In our case tr-CML developed after 2 years.…”