BCR-ABL rearrangement frequencies in chronic myeloid leukemia and acute lymphoblastic leukemia in Ecuador, South America

Paz‐y‐Miño, César; Burgos, Ramiro; Morillo, Santiago A.; Santos, Juan Carlos; Fiallo, B.Fernanda; Leone, Paola

doi:10.1016/s0165-4608(01)00515-5

Cited by 35 publications

(35 citation statements)

References 7 publications

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“…However, one study on Ecuadorian population registered a very different ratio of 95:5 [20]. Our data, which is probably the first such report on Indian population is consistent with the studies on Caucasian population and does not show any large deviation.…”

Section: Discussionsupporting

confidence: 91%

Molecular profiling of chronic myeloid leukemia in eastern India

et al. 2006

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Molecular breakpoint of the BCR-ABL fusion gene has been characterized for 122 chronic myeloid leukemia patients. Out of 122 cases, 33 b2a2, 69 b3a2, 2 e1a2, and 2 e19a2 cases have been detected. Six coexpressed both b2a2 and b3a2 transcripts. All the coexpressing samples had an A>G polymorphism at the putative splice branchpoint in intron 13. The T>C polymorphism in exon 13, reported to be linked to coexpression, was not present in all the coexpressing patients. No correlation of transcript type with platelet count was detected. Those expressing b2a2 transcript were diagnosed at relatively younger age and with higher white blood cell count, in agreement with other reports. However, the correlation was not statistically significant. Am. J. Hematol. 81:845-849, 2006. V V C 2006 Wiley-Liss, Inc.

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Section: Discussionsupporting

confidence: 91%

Molecular profiling of chronic myeloid leukemia in eastern India

et al. 2006

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“…Most frequent cytogenetic abnormalities were b3a2, b2a2 and b3a2+b2a2 found in 70%, 34% and 2% of cases respectively ( Table 2). The findings are in keeping with previous studies from Western countries [17][18][19][20][21]. However, another previous study had reported less frequency of b3a2 and b2a2 in 55% and 40% [6] of cases [22] respectively.…”

Section: Disscussionsupporting

confidence: 92%

The cytogenetic and molecular analysis of chronic myeloid leukemia in a tertiary care hospital of Sindh, Pakistan

Ujjan¹,

Akhund²,

Baig³

et al. 2015

Integr Cancer Sci Therap

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We performed a Cross sectional study to determine the frequency of Philadelphia chromosome and frequency of standard and variant translocation in chronic myeloid leukemia cases by the collaboration of Pathology department of Liaquat University of Medical and Health Sciences, Jamshoro and Isra University Hospital, Hyderabad from May to September 2014. A sample of 145 diagnosed cases of CML was selected according to inclusion. Bone marrow and peripheral Blood samples were collected in sodium heparinized bottles. Cytogenetic analysis was performed by karyotyping according to ISCN guidelines for human cytogenetic nomenclature using cytovision system for image analysis, reverse transcription polymerase chain reaction (RT-PCR) was performed to identify the various BCR-ABL transcripts. Ph+ and Ph-chromosomes were noted in 133 (91.7) and 12 (8.2%) of cases respectively. Of 133 Ph+ chromosome, standard chromosome was noted in 121 (90.9%), simple variant in 9 (6.7) and complex variants were noted in 3 (2.2%) of cases. Ph + 133 (91.7%) showed bcr-abl positivity in all subjects. Of 12 (8.2%) Ph-subjects, 7 (%) were bcr-abl positive and 5 (%) were bcr-able negative. Sensitivity and specificity of bcr-abl transcripts was calculated at 95% and 100% respectively. The present study reports Philadelphia chromosome in 90.9% and variant cytogenetic abnormalities are low similar to reported from other countries. Proper assessment of the variant translocations requires better categorization of these translocations.

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“…The distribution of transcript type has been studied in European and some other populations (Eisenberg et al, 1988;Lee et al, 1989) with frequencies for b2a2 and b3a2 transcripts being roughly of the order of 40% and 55%, and that for co-expression of b3a2 and b2a2 representing 5% of the cases. A study on an Ecuadorian population, however, registered very different frequencies: 5% for b3a2 and 95% for b2a2 (Paz-y-Mino et al, 2002). In our report in Sudanese patients ( Osman et al, 2010 ), a frequency of 53.5% and 41.9% for b2a2 and b3a2, respectively, was reported, values that are relatively closer to those from a Mexican population (Arana- Trejo et al, 2002).…”

Section: Gene and Chromosomal Rearrangementssupporting

confidence: 59%

“…Which draw another important conclusion on the significance of the types of BCR-ABL fusion transcripts among populations in relation to vaccine development? The frequencies of the types of the fusion transcript in Ecuadorian population for example consist of 95% b2a2 (Paz-y-Mino et al, 2002) indicating that they may not benefit much from such vaccine. Several studies estimated the types of BCR-ABL fusion transcript in CML in different populations.…”

Section: Gene and Chromosomal Rearrangementsmentioning

confidence: 99%