BDNF and NGF gene polymorphisms and urine BDNF–NGF levels in children with primary monosymptomatic nocturnal enuresis

Ece, Aydın; Coşkun, Salih; Şahin, Cahit; Tan, İlhan; Karabel, Duran; Çim, Abdullah

doi:10.1016/j.jpurol.2019.03.010

Cited by 10 publications

(23 citation statements)

References 26 publications

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“…Despite this observation, polymorphisms in the BDNF and NGF genes did not make a significant contribution to the development of nocturnal enuresis. 30 Recently, Balat et al tested the polymorphisms in the KCNJ10 gene in 97 children with nocturnal enuresis and 100 non-enuretic controls, and found that promoter polymorphism may play a role in potassium excretion, suggesting the KCNJ10 gene may be involved in the pathogenesis of nocturnal enuresis. 31 Although many genetic variants have been identified, there are few studies that have combined genetic alterations and functional imaging abnormalities.…”

Section: Hereditary Factors and Genetic Aberrationsmentioning

confidence: 99%

Pathogenesis and brain functional imaging in nocturnal enuresis: A review

Dang

Tang

2021

Exp Biol Med (Maywood)

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Nocturnal enuresis is a common and distressing developmental disease, which may cause various degrees of psychosocial stress and impairment to self-esteem in affected children as well as agitation to their parents or caregivers. Nevertheless, the etiology and pathogenesis of nocturnal enuresis are not understood. Currently, nocturnal enuresis is generally considered a multifactorial disease associated with a complex interaction of somatic, psychosocial, and environmental factors. A variety of postulations have been proposed to explain the occurrence and progression of nocturnal enuresis, including hereditary aberration, abnormal circadian rhythm of antidiuretic hormone secretion during sleep, bladder dysfunction, abnormal sleep, difficulties in arousal, neuropsychological disorders, and maturational delays of the brain. In recent decades, the introduction of functional neuroimaging technologies has provided new approaches for uncovering the mechanisms underlying nocturnal enuresis. The main neuroimaging modalities have included brain morphometry based on structural magnetic resonance imaging (MRI), task-based and event-related functional MRI (fMRI), and resting-state fMRI. The relevant studies have indicated that nocturnal enuresis is associated with functional and structural alterations of the brain. In this review, we briefly summarized the popular hypotheses regarding the pathogenesis of nocturnal enuresis and the current progress of functional neuroimaging studies in examining the underlying mechanisms thereof.

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Section: Hereditary Factors and Genetic Aberrationsmentioning

confidence: 99%

Pathogenesis and brain functional imaging in nocturnal enuresis: A review

Dang

Tang

2021

Exp Biol Med (Maywood)

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“…Pensa-se que estas variações estão relacionadas com a substituição dos mecanismos imaturos da micção, restritos à medula espinhal (caraterísticos da função urinária involuntária presente na infância), por circuitos mais complexos que envolvem não só a medula espinhal, mas também centros supraespinhais, responsáveis pela micção voluntária caraterística dos adultos 164 . Não é, portanto, de admirar que um estudo recente tenha associado alterações nos níveis de BDNF a casos de incontinência noturna infantil 166 . Estes dados confirmam a importância do BDNF na reorganização dos tratos neuronais responsáveis pela função urinária, embora os seus locais exatos de produção continuem por identificar.…”

Section: Fator Neurotrófico Derivado Do Cérebro Na Bexigaunclassified

As neurotrofinas e a dor visceral: o caso particular do fator de crescimento neuronal e do fator neurotr�fico derivado do c�rebro

Ferreira¹,

Coelho²,

Duarte-Cruz³

2021

DOR

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Neutrophins (NTs), particularly the nerve growth factor (NGF) and the brain derived neurotrophic factor (BDNF), have been attracting particular attention in the context of visceral function. In this work, we examine the current literature and present an embracing vision about the synthesis of these proteins in peripheric systems, as well as their role in the development of the most common visceral pain syndromes. After initial studies linking NGF to IC (interstitial cystitis/bladder pain syndrome), a lot of research has been done about NGF and its role in the development of urinary tract pathologies. In fact, it is now widely accepted that NGF is also a player in other visceral conditions such as CP/CPPS (chronic prostatitis/chronic pelvic pain syndrome) or IBS (irritable bowel syndrome). More recently, BDNF was also proved to play an important role in the same visceral dysfunctions, suggesting that both NTs are determinant factors in visceral pathophysiological mechanisms. While manipulation of NGF and BDNF improves visceral function and reduce pain, suggesting that clinical modulation of these NTs may be important, much is still to be investigated before this step is taken. Another important field of research has been focused on the urinary NGF and BDNF and its use as biomarkers. Several studies have showed that both NTs are present in much higher concentrations in the urine of patients with visceral dysfunctions than in healthy patients, pinpointing to the possible use of these urinary NTs as diagnosis biomarkers. Nevertheless, there are still non-answered scientific questions and technical difficulties that need to be overcome in order to fully understand the real relevance of the urinary NTs as possible clinical biomarkers.

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“…Delayed neuronal maturation has been suggested as a pathogenetic mechanism in primary monosymptomatic nocturnal enuresis (PMNE). Neurotrophin gene polymorphisms did not signi icantly contribute to the development of PMNE, but urine levels of neurotrophin gene products were higher in PMNE [77]. Dopamine D4 receptor (DRD4) promoter (-616; rs747302) has been associated with primary nocturnal enuresis (PNE).…”

Section: Slc6a3(dat)mentioning

confidence: 99%

Do genes matter in sleep?-A comprehensive update

Dutta¹

2020

J Neurosci Neurol Disord

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NREM sleep is found consistently to be under strong genetic control in humans and animal models as compared to REM sleep [26][27][28]. REM sleep amount was found to be signi icantly AbstractSleep is considered as a complex process in human beings and is least understood mechanism. Role of sleep in synaptic plasticity remains a debatable topic till date. Sleep is infl uenced by genetic background of the individual. EEG done in human sleep showed strong infl uence of genetic factors. A handful of familial analyses involving specifi c gene loci and twin studies has been done in this regard. In this review article focused discussion on genetic contribution to sleep phenotypes, twin and familial linkage studies and effect of genetic variation on sleep will be covered.Do genes matter in sleep?-A comprehensive update https://www.heighpubs.org/jnnd 015 https://doi.

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BDNF and NGF gene polymorphisms and urine BDNF–NGF levels in children with primary monosymptomatic nocturnal enuresis

Cited by 10 publications

References 26 publications

Pathogenesis and brain functional imaging in nocturnal enuresis: A review

Pathogenesis and brain functional imaging in nocturnal enuresis: A review

As neurotrofinas e a dor visceral: o caso particular do fator de crescimento neuronal e do fator neurotr�fico derivado do c�rebro

Do genes matter in sleep?-A comprehensive update

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