BDNF and S100B in psychotic disorders: evidence for an association with treatment responsiveness

Abstract

Serum levels of BDNF and S100B are lowered in patients with psychotic disorders across diagnostic boundaries. The differences between high and low S100B subgroups suggest a relationship between S100B, symptom dimensions and treatment response, irrespective of diagnostic categories.

Composite immune marker scores associated with severe mental disorders and illness course

“…Several studies report elevated S100B in BD ( Bartoli et al, 2020 ; da Rosa et al, 2016 ) and SCZ ( Aleksovska et al, 2014 ; Hong et al, 2016 ; Rothermundt et al, 2009 ). However, there is a positive association with symptom severity ( Futtrup et al, 2020 ; Pollak et al, 2018 ; van de Kerkhof et al, 2014 ) and reduced levels in BD after treatment of manic phase, suggesting a transient disruption of BBB that may be clinically dependent ( Tsai and Huang, 2017 ). Importantly, the current patients had relatively low symptom load, enabling putative assessment of the basal underlying BBB integrity of BD.…”

Brain-derived neurotrophic factor as a suicide factor in mental disorders

“…In recent years, studies on the role of BDNF in the aetiology, pathophysiology and treatment of mental disorders has attracted significant interest of researchers (8). Reduced levels of BDNF have been detected in those affected by schizophrenia, depression, bipolar affective disorder, eating disorders, post-traumatic stress disorder, Huntington's disease, Alzheimer's disease, autism and in those addicted to psychoactive substances (9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19). Karege et al (20) found reduced BDNF levels in those suffering from depression, which was later confirmed by Shimizu et al (21), Gervasoni et al (22), Piccinni et al (23), Aydemir et al (24), Yoshimura et al (25), Monteleone et al (26) and many others researching the association of these phenomena.…”

Peripheral S100B Protein Levels in Five Major Psychiatric Disorders: A Systematic Review

“…Results are not unequivocal because no differences between SCH and HC were reported [ 34 , 37 , 38 ]; also, lower S100B was detected in SCH compared to HC [ 39 , 40 ].…”

“…Changes in S100B levels during antipsychotic treatment were widely studied, with contrary results. No differences [ 13 , 23 , 39 , 41 , 42 , 43 , 44 , 45 , 46 ] or decreases [ 12 , 19 , 45 , 47 , 48 , 49 ] in S100B concentrations were reported during antipsychotic treatment. Elevation in S100B levels in the patient group with predominant negative symptoms were also found [ 39 ].…”