2006
DOI: 10.1016/j.modgep.2006.03.009
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BDNF and trkB mRNA expression in the hippocampus and temporal cortex during the human lifespan

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Cited by 192 publications
(143 citation statements)
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References 82 publications
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“…In contrast to our findings with age, Bdnf mRNA levels are reported to remain constant throughout adult life in rats and humans (Webster et al 2006(Webster et al , 2002Silhol et al 2008). However, these findings are somewhat confounding in that Bdnf mRNA levels are reported relative to total RNA concentration and not mass of the brain tissue.…”
Section: Discussioncontrasting
confidence: 99%
See 1 more Smart Citation
“…In contrast to our findings with age, Bdnf mRNA levels are reported to remain constant throughout adult life in rats and humans (Webster et al 2006(Webster et al , 2002Silhol et al 2008). However, these findings are somewhat confounding in that Bdnf mRNA levels are reported relative to total RNA concentration and not mass of the brain tissue.…”
Section: Discussioncontrasting
confidence: 99%
“…However, since the aged total μg RNA/mg tissue was one-half that of adults, BDNF mRNA does decline with age/mass of brain. In a follow-up study, Webster et al (2006) examined human hippocampus and temporal cortex by autoradiography with specific probes for BDNF mRNA. No agerelated changes were reported, but again the measures were made on regions of interest in autoradiographic density, which reflects concentration, not mass of BDNF mRNA/mass of total brain region.…”
Section: Discussionmentioning
confidence: 99%
“…Both the proband and the patient with a mutation in TrkB showed general impairments of intelligence, language, numeracy, attention, and memory. BDNF has been implicated in hippocampal function throughout the lifespan (22); therefore, everyday memory deficits were expected in these two patients. BDNF is known to play a role in the development and maturation of neurons in brain regions other than the hippocampus; thus, BDNF haploinsufficiency would be expected to be associated with the more general profile of cognitive dysfunction that we observed.…”
Section: Discussionmentioning
confidence: 92%
“…Under baseline conditions, BDNF and its receptor trkB are densely expressed in the hippocampal formation (Conner et al., 1997; Phillips et al., 1991; Quartu et al., 1999, 2013; Webster, Herman, Kleinman, & Weickert, 2006; Yan, Radeke, et al., 1997; Yan, Rosenfeld, et al., 1997), one of the key regions implicated in depression‐linked maladaptive neuronal plasticity (Dias, Banerjee, Duman, & Vaidya, 2003; Malberg, Eisch, Nestler, & Duman, 2000; Vaidya, Siuciak, Du, & Duman, 1999). Accordingly, the hippocampal volume is reduced in patients with post‐traumatic stress disorder (Angelucci, Brene, & Mathe, 2005), and with depression associated with the BDNF Met polymorphism, which is known to be less active than its normal variant (Autry & Monteggia, 2012).…”
Section: Introductionmentioning
confidence: 99%