BDNF gene expression association with suicide and psychiatric disorders in children and adolescents

Yılmaz, Rabia; Öztop, Didem Behice; Şener, Elif Funda; Cikili-Uytun, Merve; Dal, Fatma; Yildiz, Emrah; Şahpolat, Musa; Zararsız, Gökmen

doi:10.1016/j.bbr.2021.113350

Cited by 5 publications

(4 citation statements)

References 37 publications

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“…Previous studies examined the role of BDNF pathway in suicidality, detecting an impact of BDNF gene expression on suicidal behaviour in adolescents (Yilmaz et al, 2021). In meta-analyses strongly heterogenic data for peripheral BDNF concentration were observed (Fusar-Poli et al, 2021) with medium effect-size.…”

Section: Discussionmentioning

confidence: 99%

Plasma biomarkers in adolescents with schizophrenia‐spectrum disorder

Zakowicz

Skibińska

Waśniewski

et al. 2023

Early Intervention Psych

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AimSchizophrenia onset in the developmental age has a strong neurodevelopmental burden and is associated with a poorer prognosis. The approach to diagnosis is still based on symptomatic description without objective validation. In this study, we aimed to compare the peripheral blood levels of hypothesized biomarker proteins: brain‐derived neurotrophic factor (BDNF), proBDNF, p75 neurotrophin receptor (p75NTR) and S100B between early‐onset schizophrenia‐spectrum adolescents (n = 45) and healthy controls (n = 34).MethodsClinical assessment of the participants encompassed symptomatic description with the use of structured interviews and executive function objective measurement. Plasma levels of BDNF protein were significantly lower in schizophrenia patients than in controls both at admission (p = .003) and 6–8 weeks follow‐up (p = .007).ResultsWe observed significant correlations between BDNF, proBDNF and p75NTR levels and positive and negative symptoms scale (PANSS) scores, p75NTR and S100B levels and suicidal parameters, as well as a correlation of BDNF plasma level with the risky decision‐making style in Iowa Gambling Task (IGT).ConclusionsThe results indicate a potential value of studied proteins as a biomarker in the diagnosis and monitoring of the disease's course.

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Section: Discussionmentioning

confidence: 99%

Plasma biomarkers in adolescents with schizophrenia‐spectrum disorder

Zakowicz

Skibińska

Waśniewski

et al. 2023

Early Intervention Psych

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“…Nevertheless, some studies also document practical results, which holds a promise for the future. From a representative sample of 100 children and adolescents who had previously attempted suicide, it was shown by comparison with 100 healthy children that the children with psychiatric distress had signifi cantly higher gene expression of BDNF (Brain Derived Neurotrophic Factor) compared with the healthy children (28). Thus, it is clear that laboratory parameters will play some role in the future in the prediction of potential suicidal ideation.…”

Section: Discussionmentioning

confidence: 99%

Suicides and their preventive interventions possibilities: are there some relationships between mechanisms and different mental disorders?

MATLACH,

MAKOVICKA,

MIKLOSOVA

et al. 2023

BLL

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Suicides are one of the topics discussed around the world. This problem receives large space in scientifi c and professional literature, in order to eliminate its occurrence. Mechanisms of suicides are determined by whole spectrum of reasons determined by/depending on physical and psychological health. The objective of this work is to document the differences in mechanisms and realization of suicides by mentally sick people. Ten cases of suicides are reported in the article: three of which in people with a history of depression of the victim noted by family members, one with treated depression, three with anxiety-depressive disorder and three schizophrenic patients cases. There are fi ve men and fi ve women. Four of these women overdosed themselves by medicaments and one jumped out of a window. Two men shot themselves, two hanged themselves and one jumped out of a window. Persons without anamnestically proven psychiatric diseases end their lives mostly because of inconclusive situation or as a result of balancing their whole life (usually with good plan and preparation of the act). Persons with treatment of depression or anxiety-depressive disorder kill themselves mostly after several "unsuccessful" attempts. In case of victims with schizophrenia suicides follow a hardly predictable sequence of actions which sometimes do not seem to have any logic. Differences have been found between victims with and without mental disorders in ways of realization of suicides. Psychological predispositions in mood changes, long-term sadness and threatening suicide should be recognized by family members. Prevention of suicides in cases of people with a history of mental disorders is based on medical treatment and cooperation between the client and family members and a psychiatrist (Ref. 30).

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“…Still, research results do not always support the idea that these dimensions of problem solving are involved in suicidality. For instance, some authors observed nonsignificant relationships between suicidality and problem-solving control (e.g., Priester & Clum, 1993; Yilmaz et al, 2021), problem-solving confidence (Yilmaz et al, 2021), and positive problem orientation (Fitzpatrick, Witte, & Schmidt, 2005). These findings call for a more thorough examination of the available data surrounding the relationship between adaptive problem-solving strategies and suicidality.…”

Section: Adaptive and Maladaptive Er Strategies: The Role Of Contextmentioning

confidence: 99%

The multifaceted role of emotion regulation in suicidality: Systematic reviews and meta-analytic evidence.

Rogier,

Chiorri,

Beomonte Zobel

et al. 2024

Psychological Bulletin

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BDNF gene expression association with suicide and psychiatric disorders in children and adolescents

Cited by 5 publications

References 37 publications

Plasma biomarkers in adolescents with schizophrenia‐spectrum disorder

Plasma biomarkers in adolescents with schizophrenia‐spectrum disorder

Suicides and their preventive interventions possibilities: are there some relationships between mechanisms and different mental disorders?

The multifaceted role of emotion regulation in suicidality: Systematic reviews and meta-analytic evidence.

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