BDNF induces in vivo long-lasting enhancement of synaptic transmission and structural reorganization at the hippocampal mossy fibers in a transcription and translation-independent manner

Martínez-Moreno, Araceli; Rivera-Olvera, Alejandro; Escobar, Martha L.

doi:10.1016/j.nlm.2019.107125

Cited by 9 publications

(2 citation statements)

References 60 publications

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“… 44 BDNF has been shown to play a crucial modulatory role in many CNS processes, including synaptic plasticity, new synapse formation, neuronal survival, dendritic branching, and neurotransmitter excitation and inhibition. 45 – 47 Similar findings were found in animal studies, where elevation of BDNF levels resulted in an increased rate and extent of myelination and to a lesser degree, the axon caliber. This increased myelin content and caliber was maintained in adulthood.…”

Section: Discussionsupporting

confidence: 78%

Serum brain injury biomarkers are gestationally and post-natally regulated in non-brain injured neonates

et al. 2021

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Objective: To determine the association of gestational age (GA) and day of life (DOL) with the circulating serum concentration of six brain injury-associated biomarkers in non-brain injured neonates born between 23–41 weeks’ GA. Methods: In a multicenter prospective observational cohort study, serum CNS-insult, inflammatory and trophic proteins concentrations were measured daily in the first 7 DOL. Results: 3232 serum samples were analyzed from 745 enrollees, median GA 32.3 weeks. BDNF increased 3.7% and IL-8 increased 8.9% each week of gestation. VEGF, IL-6, and IL-10 showed no relationship with GA. VEGF increased 10.8% and IL-8 18.9%, each DOL. IL-6 decreased by 15.8% each DOL. IL-10 decreased by 81.4% each DOL for DOL 0–3. BDNF did not change with DOL. Only 49.67% of samples had detectable GFAP and 33.15% had detectable NRGN. The odds of having detectable GFAP and NRGN increased by 53% and 11%, respectively, each week after 36 weeks’ GA. The odds of having detectable GFAP and NRGN decreased by 15% and 8%, respectively, each DOL. Conclusion: BDNF and IL-8 serum concentrations vary with GA. VEGF and interleukin concentrations are dynamic in the first week of life, suggesting circulating levels should be adjusted for GA and DOL for clinically relevant assessment of brain injury.

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Section: Discussionsupporting

confidence: 78%

Serum brain injury biomarkers are gestationally and post-natally regulated in non-brain injured neonates

et al. 2021

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“…Houeland et al [48] reported that NGF deprivation causes Alzheimer-like pathologies, such as amyloid-β accumulation, synaptic dysfunction and memory deficits, and NGF treatment can reverse these pathological changes. BDNF activates TrkB and enhances synaptic plasticity, memory formation and memory storage persistence [49,50]. Moreover, studies on animal models showed that an increase in BDNF and NGF expression is effective in improving memory impairment and depression.…”

Section: Discussionmentioning

confidence: 99%

Sulfated Polysaccharide Isolated from the Nacre of Pearl Oyster Improves Scopolamine-Induced Memory Impairment

et al. 2021

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Pearl and nacre have been used in traditional medicines for treating brain dysfunctions, such as epilepsy, myopia, palpitations and convulsions. We previously showed that a pearl oyster nacre extract improves scopolamine-induced memory impairments using the Y-maze, Banes maze and object recognition tests. In this study, we aimed to isolate the memory-improving substance using ion-exchange column chromatography and reverse-phase column chromatography and elucidate the molecular mechanism underlying its memory-improving activity. The isolated substance was found to be a sulfated polysaccharide with a molecular weight of approximately 750 kDa. Monosaccharide composition analysis showed that it was rich in galactose, glucose, mannose and uronic acid. Furthermore, the mRNA expression levels of oxidative stress, inflammatory response and neuroprotective factors in the cerebral cortex were investigated. Treatment with the polysaccharide increased the expression levels of the antioxidant enzymes Cu, Zn -superoxide dismutase (SOD) and catalase and attenuated the scopolamine-mediated upregulation of the inflammatory cytokines interleukin-1 and interleukin-6. In addition, the polysaccharide suppressed the decrease in the expression levels of brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF). These findings strongly suggest that the polysaccharide in the nacre extract mediated its antiamnesic effects by preventing oxidative stress and inflammation and increasing the expression levels of BDNF and NGF.

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Behavioral changes and brain epigenetic alterations induced by maternal deficiencies of B vitamins in a mouse model

Pang

Zhou

et al. 2021

Psychopharmacology

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BDNF induces in vivo long-lasting enhancement of synaptic transmission and structural reorganization at the hippocampal mossy fibers in a transcription and translation-independent manner

Cited by 9 publications

References 60 publications

Serum brain injury biomarkers are gestationally and post-natally regulated in non-brain injured neonates

Serum brain injury biomarkers are gestationally and post-natally regulated in non-brain injured neonates

Sulfated Polysaccharide Isolated from the Nacre of Pearl Oyster Improves Scopolamine-Induced Memory Impairment

Behavioral changes and brain epigenetic alterations induced by maternal deficiencies of B vitamins in a mouse model

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