BDNF levels are increased in peripheral blood of middle-aged amateur runners with no changes on histone H4 acetylation levels

Abstract

Our aim was to compare the basal levels of plasma brain-derived neurotrophic factor (BDNF) and global histone H4 acetylation in peripheral blood mononuclear cells (PBMCs) of healthy amateur runners (EXE group) with sedentary individuals (SED group) as well as to investigate the acute effect of a running race on these markers in the EXE group. Five days before the race, all participants were submitted to a basal blood collection. On the race day, two blood samples were collected in the EXE group before the running started and immediately at the end. In the basal period, a significant increase of plasma BDNF levels in the EXE individuals when compared to the SED group (p = 0.036) was demonstrated, while no difference in global histone H4 acetylation levels was observed. These parameters were unaltered in the EXE group after the race. The increased levels of BDNF might be linked to healthy middle-aged runners' phenotype.

Running-induced Functional Mobility Improvement in the Elderly Males is Driven by Enhanced Plasma BDNF Levels and the Modulation of Global Histone H4 Acetylation Status

“…The current study data corroborates those obtained by Zoladz et al (21) who showed that basal plasma BDNF levels were higher in young, well-trained athletes including sprinters, jumpers, and runners, compared with untrained participants. In agreement, da Silveira et al (30) also showed that plasma BDNF levels increased in middle-aged amateur runners compared to the sedentary group.…”

“…In this sense, the current study was the first to show that exercise modulates the acetylation status in the elderly people, indicating that histone H4 acetylation can be considered as a novel biomarker that reacts epigenetically to physical activity in this population. On the other hand, a recent study (30) reported no difference in histone H4 acetylation levels between middle-aged runners and sedentary individuals. These findings were in agreement with the experimental studies reporting that histone acetylation status in response to exercise might act in an age-dependent manner (8,36).…”

Different doses of methamphetamine alter long-term potentiation, level of BDNF and neuronal apoptosis in the hippocampus of reinstated rats

“…Immediately following LTP recordings, some animals were sacrificed by rapid decapitation, and the hippocampus was removed and immediately frozen in liquid N 2 . The western blotting method was performed as in previous study procedures [29,51,52].…”

“…Additionally, BDNF is essential to regulation of activity-dependent pre-synaptic vesicle cycling, which is dependent on N-methyl D-aspartate (NMDA) receptor activation in cultured neocortical neurons from BDNF-knockout mice [27]. Furthermore, increasing of BDNF is associated with enhancing of NMDA expression and intracellular calcium concentrations [28,29], thereby promoting long-term changes to synaptic activity.…”

Grape juice consumption and/or exercise training-induced neuroplasticity and memory improvement in healthy elderly women

“…Importantly, BDNF can cross the blood-brain barrier in a bidirectional manner, as well it was also reported that the peripheral levels of this neurotrophin seem to present a strong correlation with cerebrospinal fluid levels [8]. Therefore, plasma BDNF levels have been used as a biomarker in several clinical studies [9][10][11]. In view of all these considerations, strategies that modulate peripheral levels of BDNF should be consider important tools among elderly.…”