BDNF Methylation and Suicidal Ideation in Patients with Acute Coronary Syndrome

Kang, Hee‐Ju; Bae, Kyung‐Yeol; Kim, Sung‐Wan; Shin, Il‐Seon; Hong, Young Joon; Ahn, Youngkeun; Yoon, Jin‐Sang; Kim, Jae-Min

doi:10.30773/pi.2018.09.20

Cited by 11 publications

(8 citation statements)

References 19 publications

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“…Our study further found that patients with high suicide risk had lower serum VGF than those at low risk, and that the risk of suicide was negatively correlated with the level of VGF. Consistent with our present study, previous studies demonstrated that the lower levels of neuropeptide Y in the prefrontal cortex and caudate nucleus of suicide victims [27], and Kang et al found that hypermethylation of brain-derived neurotrophic factor (BDNF) plays a role in the epigenetic susceptibility of patients with acute coronary syndrome who have a history of suicidal ideation [28]. Taken together, these studies suggest that the VGF as one critical neuropeptides is also closely related to suicide risk.…”

Section: Discussionsupporting

confidence: 92%

Reduced serum VGF levels are linked with suicide risk in Chinese Han patients with major depressive disorder

Zhou

et al. 2020

BMC Psychiatry

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Background: VGF (nonacronymic) is a neuropeptide that plays an important role in the pathogenesis of major depressive disorder (MDD). However, no studies have yet investigated VGF levels in patients with MDD who are at risk of suicide. The purpose of the present study was to determine whether serum VGF levels are related to suicide risk in patients with MMD. Methods: A total of 107 patients with MDD and 40 normal control participated in the present study. The risk of suicide was assessed using the Nurses Global Assessment of Suicide Risk (NGASR). On this basis, 60 patients were assigned to a high-risk group (NGASR≥9) and 47 were assigned to a low-risk group (NGASR< 9). The severity of depression was measured using the 17-item Hamilton Depression Rating Scale (HDRS). Levels of serum VGF were determined using a double antibody sandwich enzyme-linked immunosorbent assay. Results: Serum VGF levels in the high-risk group (883.34 ± 139.67 pg/mL) were significantly lower than in the lowrisk group (1020.56 ± 131.76 pg/mL) and in the control group (1107.00 ± 155.38 pg/mL) (F = 31.90, p < 0.001). In patients with MDD, suicide risk was significantly negatively correlated with VGF levels (r = − 0.55, p = 0.001). Conclusions: Reduced serum VGF levels are related to risk of suicide in patients with MDD, so VGF may be a biomarker of suicide risk in MDD.

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Section: Discussionsupporting

confidence: 92%

Reduced serum VGF levels are linked with suicide risk in Chinese Han patients with major depressive disorder

Zhou

et al. 2020

BMC Psychiatry

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“…The most commonly studied gene system was BDNF ( N = 10, including two studies investigating the TrkB.T1 gene; Kang et al, 2018; Ropret, Kouter, Zupanc, & Videtic Paska, 2021; Roy, Shelton, & Dwivedi, 2017; Kim et al, 2015; Kim et al, 2014; Maussion et al, 2014; Kang et al, 2013; Keller et al, 2011; Keller et al, 2010; Ernst et al, 2009). Of the eight studies examining methylation specifically in the BDNF gene, six found BDNF hypermethylation to be implicated across a range of SITB outcomes, while one study of SI found no group differences (Roy, Wang, Palkovits, Faludi, & Dwivedi, 2017), and an SD study found hypomethylation (Ropret et al, 2021).…”

Section: Resultsmentioning

confidence: 99%

Genetics and epigenetics of self‐injurious thoughts and behaviors: Systematic review of the suicide literature and methodological considerations

Mirza

Docherty

Bakian

et al. 2022

American J of Med Genetics Pt B

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Suicide is a multifaceted and poorly understood clinical outcome, and there is an urgent need to advance research on its phenomenology and etiology. Epidemiological studies have demonstrated that suicidal behavior is heritable, suggesting that genetic and epigenetic information may serve as biomarkers for suicide risk. Here we systematically review the literature on genetic and epigenetic alterations observed in phenotypes across the full range of self-injurious thoughts and behaviors (SITB). We included 577 studies focused on genome-wide and epigenome-wide associations, candidate genes (SNP and methylation), noncoding RNAs, and histones. Convergence of specific genes is limited across units of analysis, although pathway-based analyses do indicate nervous system development and function and immunity/inflammation as potential underlying mechanisms of SITB. We provide suggestions for future work on the genetic and epigenetic correlates of SITB with a specific focus on measurement issues.

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“…Previous studies on blood from elderly people and patients with psychiatric or other conditions who also showed suicidal behavior ( i.e. suicide ideation, suicide attempts) have reported increased BDNF methylation over the controls[ 21 - 25 ]. To the best of our knowledge, there are only two studies to date that have reported decreased BDNF methylation in blood of psychiatric patients compared to controls.…”

Section: Discussionmentioning

confidence: 99%

BDNF methylation and mRNA expression in brain and blood of completed suicides in Slovenia

Ropret¹,

Kouter²,

Zupanc³

et al. 2021

WJP

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BACKGROUND Suicide is a major public health problem. Worldwide, around 800000 people die by suicide every year. Suicide is a multifactorial disorder, with numerous environmental and genetic risk factors involved. Among the candidate genes, changes in the BDNF locus at the gene, epigenetic, mRNA, and protein expression levels have been implicated in psychiatric disorders, including suicidal behavior and completed suicides. AIM To investigate changes in BDNF methylation and expression of four alternative BDNF transcripts for association with completed suicide. METHODS This case-control study included 42 unrelated male Caucasian subjects, where 20 were control subjects who died following acute cardiac arrest, and 22 were suicide victims who died by hanging. DNA and RNA were extracted from brain tissue (Brodmann area 9 and hippocampus) and from blood. DNA methylation and mRNA expression levels were determined by targeted bisulfite next-generation sequencing and reverse-transcription quantitative PCR. Statistical analysis was done by use of two-tailed Student’s t tests for two independent samples, and the Benjamini-Hochberg procedure was implemented for correction for multiple comparisons. RESULTS In DNA from brain tissue, there were no significant differences in BDNF methylation between the study groups. However, data showed significantly reduced DNA methylation of the BDNF region upstream of exon I in blood samples of suicide victims compared to the controls (5.67 ± 0.57 vs 6.83 ± 0.64, P corr = 0.01). In Brodmann area 9 of the brain of the suicide victims but not in their hippocampus, there was higher expression of BDNF transcript I-IX (NM_170731.4) compared to the controls (0.077 ± 0.024 vs 0.05 ± 0.013, P = 0.042). In blood, expression analysis for the BDNF transcripts was not feasible due to extensive RNA degradation. CONCLUSION Despite the limitations of the study, the obtained data further support a role for BDNF in suicidality. However, it should be noted that suicidal behavior is a multifactorial disorder with numerous environmental and genetic risk factors involved.

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BDNF Methylation and Suicidal Ideation in Patients with Acute Coronary Syndrome

Cited by 11 publications

References 19 publications

Reduced serum VGF levels are linked with suicide risk in Chinese Han patients with major depressive disorder

Reduced serum VGF levels are linked with suicide risk in Chinese Han patients with major depressive disorder

Genetics and epigenetics of self‐injurious thoughts and behaviors: Systematic review of the suicide literature and methodological considerations

BDNF methylation and mRNA expression in brain and blood of completed suicides in Slovenia

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