BDNF Serum Concentrations in Healthy Volunteers are Associated with Depression-Related Personality Traits

Lang, Undine E.; Hellweg, Rainer; Gallinat, Jürgen

doi:10.1038/sj.npp.1300382

Cited by 199 publications

(115 citation statements)

References 30 publications

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“…As previously reported (Lang et al, 2004; n ¼ 118), a significant negative correlation between BDNF serum concentration and the depression-related personality trait neuroticism was observed. This was also observed in the present subsample (n ¼ 109; r ¼ À0.193; p ¼ 0.048; partial correlation controlled for age), indicating a lower BDNF concentration in subjects with a more depressed personality trait.…”

Section: Resultssupporting

confidence: 87%

“…In analogy with the neurotrophin hypothesis of depression, low BDNF serum levels were found to be associated with high scores in depressive personality traits in healthy subjects (Lang et al, 2004). In line with this, genetic studies show that a BDNF-coding variant is associated with neuroticism in the NEO personality inventory (Sen et al, 2003).…”

Section: Discussionmentioning

confidence: 75%

“…A total of 109 healthy unrelated volunteers (62 male, 47 female, age: 42.52713.1) were investigated. All participants were also part of a sample (n ¼ 118) reporting a correlation between BDNF serum concentration and personality traits (Lang et al, 2004) as well as part of a sample (n ¼ 185) analysing the association between allelic variants of the serotonin transporter gene and the LD .…”

Section: Subjectsmentioning

confidence: 99%

“…This hypothesis was investigated in 109 carefully selected healthy subjects, who were also have been part of previously investigated samples (Lang et al, 2004;Gallinat et al, 2003).…”

Section: Introductionmentioning

confidence: 99%

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Association of BDNF Serum Concentrations with Central Serotonergic Activity: Evidence from Auditory Signal Processing

Lang

Hellweg

Gallinat

2005

Neuropsychopharmacol

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Disturbances of serotonergic neurotransmission in the brain have been implicated in the pathogenesis and maintenance of several psychiatric disorders. According to recent preclinical and clinical studies, the loudness dependence of auditory evoked potentials (LD) is related to the central serotonergic neurotransmission in humans. As the serotonergic phenotype has been reported to be associated with brain-derived neurotrophic factor (BDNF), we studied whether BDNF serum concentrations are related to LD in 109 healthy human volunteers (62 male, 47 female, age: 42.5713.1 years). Pearson correlation showed a significant negative correlation between the BDNF serum concentrations and the LD measured at Fz (r ¼ À0.259, p ¼ 0.007) and a trend for the Cz electrode (r ¼ À0.185, p ¼ 0.055). Although this association needs to be replicated, the results are in line with the assumption that low serum BDNF levels reflect low central serotonergic neurotransmission as indicated by a strong LD.

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Section: Resultssupporting

confidence: 87%

Section: Discussionmentioning

confidence: 75%

Section: Subjectsmentioning

confidence: 99%

“…This hypothesis was investigated in 109 carefully selected healthy subjects, who were also have been part of previously investigated samples (Lang et al, 2004;Gallinat et al, 2003).…”

Section: Introductionmentioning

confidence: 99%

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Association of BDNF Serum Concentrations with Central Serotonergic Activity: Evidence from Auditory Signal Processing

Lang

Hellweg

Gallinat

2005

Neuropsychopharmacol

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“…[24][25][26][27][28][29] Further evidence implicating the BDNF locus' involvement in mood disorders arises from studies of neuroticism, a trait highly correlated with depression. [30][31][32][33] We have recently described an association between the BDNF (GT) n marker and a haplotype containing the Val 66 Met val allele with COMD in 93 case-control pairs. 34 Overall, substantial reason exists to further examine BDNF as a candidate gene for depressive disorders such as COMD.…”

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confidence: 99%

Brain-derived neurotrophic factor variants are associated with childhood-onset mood disorder: confirmation in a Hungarian sample

et al. 2005

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Brain-derived neurotrophic factor (BDNF) is a nerve growth factor that has been implicated in the neurobiology of depression. Our group has previously reported an association between a BDNF variant and childhood-onset mood disorder (COMD) in an adult sample from Pittsburgh. We hypothesize that variants at the BDNF locus are associated with COMD. Six BDNF polymorphisms were genotyped in 258 trios having juvenile probands with childhood-onset DSM-IV major depressive or dysthymic disorder. Keywords: neurotrophic factors; mood disorder; childhood-onset; genetic association; haplotype Mood disorders rank fourth among the most significant global public health problems. 1 The prevalence of the juvenile-onset subtype of depressive disorder increases dramatically across the years of childhood and adolescence, with an estimated lifetime prevalence close to 20% by late adolescence. 2 Juvenile-onset mood disorders are associated with serious morbidity, including recurrence, impaired interpersonal functioning, and increased risks of bipolar disorder and suicide. 2,3 The influence of hereditary factors on susceptibility to major depression has been documented based on twin and adoption studies. 4 Twin studies in youth have identified significant heritability for depressive symptoms. 5,6 It has also been proposed that genetic aspects of liability to mood disorder may be more readily identified in families of childhood-and adolescentonset probands. 7 Accordingly, first-degree relatives of childhood-onset mood disorder probands have higher rates of affective disorder than do first-degree relatives of adult-onset mood disorder probands. 8 Evidence from both preclinical and clinical studies implicates brain-derived neurotrophic factor (BDNF) in mood disorders. Altered BDNF expression in stress-related depression via cellular signalling has been described in animal models. Repeated antidepressant administration, including electroconvulsive seizures, is associated with increased hippocampal BDNF expression, neuronal plasticity and neurogenesis. 9-11 Human neuroimaging 12,13 post mortem 14 and clinical [15][16][17] investigations indirectly support the hypothesis that neurotrophic factors play a key role in depression. As well, human linkage studies in

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Neurotrophic Factors in Etiology and Treatment of Mood Disorders

Duman

2007

Handbook of Contemporary Neuropharmacology

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Basic and clinical research has demonstrated a role for neurotrophic factors in the pathophysiology and treatment of mood disorders, contributing to a neurotrophic hypothesis of depression. Animal studies report that stress decreases the expression of brain derived neurotrophic factor (BDNF), as well as other trophic factors, in limbic brain structures, which could contribute to the atrophy and cell loss caused by stress and depression. In contrast, antidepressant treatment increases the expression of BDNF and increases the birth of newborn neurons in the adult hippocampus, effects that could block or even reverse the effects of stress. BDNF also produces antidepressant effects in behavioral models, further demonstrating the functional significance of this neurotrophic factor. The relevance of the basic research studies is supported by clinical studies demonstrating that levels of BDNF in brain and plasma of depressed patients is decreased relative to controls and that this effect is reversed by antidepressant treatments. Genetic studies are underway to identify polymorphisms of the BDNF gene that could directly contribute to depressive symptoms or increase vulnerability upon exposure to stress or other environmental factors. These findings further elucidate the cellular alterations underlying mood disorders and could lead to novel therapeutic interventions.

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BDNF Serum Concentrations in Healthy Volunteers are Associated with Depression-Related Personality Traits

Cited by 199 publications

References 30 publications

Association of BDNF Serum Concentrations with Central Serotonergic Activity: Evidence from Auditory Signal Processing

Association of BDNF Serum Concentrations with Central Serotonergic Activity: Evidence from Auditory Signal Processing

Brain-derived neurotrophic factor variants are associated with childhood-onset mood disorder: confirmation in a Hungarian sample

Neurotrophic Factors in Etiology and Treatment of Mood Disorders

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