BDNF Val66Met genotype modulates the effect of childhood adversity on subgenual anterior cingulate cortex volume in healthy subjects

Effects of the BDNF Val66Met Polymorphism on White Matter Microstructure in Healthy Adults

“…Other methodological differences include varying procedures for statistical inference that included parametric (Chiang et al, 2011;Kennedy et al, 2009;Voineskos et al, 2011) and nonparametric approaches (used here and in Montag et al (2010) and Soliman et al (2010)). Another possible explanation for the variability of findings regarding the main effect of BDNF Val 66 Met on DTI measures is a possible effect of early life experience, which has been reported to interact with BDNF Val 66 Met to determine other brain and behavioral phenotypes (Gatt et al, 2009;Gerritsen et al, 2011). Data on early adversity were not collected in this or in any of the other studies reporting on diffusion metrics and BDNF.…”

“…Specifically, brain-derived neurotrophic factor (BDNF) has been identified as a key regulator of synaptogenesis and memory formation, particularly in the medial temporal lobe (Minichiello, 2009). A frequent non-synonymous coding variant in the 5 0 proregion of the BDNF gene (Val 66 Met,rs6265) has been linked to abnormal activity-dependent secretion of BDNF, deficits in neural activation and cognition (Egan et al, 2003), the modulation of other genes (Pezawas et al, 2008;Tan et al, 2011) and the effects of environmental adversity on neural structure and function (Gatt et al, 2009;Gerritsen et al, 2011). Considering its pivotal role in neurodevelopment and adaptation, the variant has also received considerable attention as a candidate gene locus for mental disorder and treatment response (Martinowich et al, 2007).…”

P.1.i.021 Improvement of well-being measures after regular physical exercise correlates with resting state connectivity in attentional and default mode networks

“…through the brain-derived neurotrophic factor (BDNF) pathway. In addition, susceptibility for CM may be genetically determined as previous studies have reported an interaction between CM and BDNF genotype on brain volume [4,5]. However, findings on CM and BDNF pathway as determinants of brain volume are inconsistent and have never accounted for the entire BDNF pathway.…”

“…There were no significant differences in ADC values in ROIs: 8 and 9 between MS1 and CG. However, in ROI 6 the ADC values were significantly lower (p < 0.01), while in ROIs: 10 and 11 significantly higher (p < 0.01) in MS1 group in comaprison with CG.No other statistically significant differences were found between groups: MS0 and CG, MS1 and CG, as well as MS0 and MS1.Conclusions Recently, MRI studies have found that an increased functional connectivity is found after prolonged regular physical exercise in brain networks in the resting state, such as the default mode network (DMN), the fronto-parietal network and in areas of the affective network and that this increase correlates with an improvement of executive function [3,4].Aims: Our study aimed to assess resting state modifications across known brain networks after an extensive period of physical exercise and to investigate their correlations with behavioural measures of mood state and perceived health.Methods: Thirty-eight healthy participants were recruited. They were then randomised to either participate to an aerobic exercise programme twice a week for 16 weeks or to be part of a control group.…”

“…Recently, MRI studies have found that an increased functional connectivity is found after prolonged regular physical exercise in brain networks in the resting state, such as the default mode network (DMN), the fronto-parietal network and in areas of the affective network and that this increase correlates with an improvement of executive function [3,4].…”