BE-ACTIV for Depression in Nursing Homes: Primary Outcomes of a Randomized Clinical Trial

Meeks, Suzanne; Haitsma, Kimberly Van; Schoenbachler, Ben; Looney, Stephen W.

doi:10.1093/geronb/gbu026

Cited by 87 publications

(52 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…(The difference between groups on “increased depression severity” approached significance; as might be expected given the results of the clinical trial (Meeks et al, 2015) the control group had more recorded instances of this adverse event). There were 13 falls reported over 20,739 person-days of follow-up, or an average of 252.91 days per participant (range: 9 to 336 days).…”

Section: Resultsmentioning

confidence: 62%

“…We analyzed data from a cluster-randomized controlled trial of a 10-week psychosocial treatment for depression designed to increase activation through increasing pleasant events (Meeks, Looney, Van Haitsma, & Teri, 2008; see Meeks et al, 2015, for primary outcomes and clinical trial details). Briefly, 23 nursing facilities from Kentucky and Indiana were randomly assigned to either the experimental or treatment-as-usual (TAU) conditions.…”

Section: Methodsmentioning

confidence: 99%

“…Adverse events are not frequently analyzed in clinical trials for behavioral interventions, and little is known about falls as an adverse event secondary to psychosocial treatments for depression. As a part of our data safety and management plan in a clinical trial of a behavioral intervention for depression (Meeks, Van Haitsma, Schoenbachler, & Looney, 2015), we tracked and analyzed adverse events. The purpose of the present study was to assess the risk of falls associated with a psychosocial depression treatment.…”

mentioning

confidence: 99%

See 2 more Smart Citations

Falls as adverse events in psychosocial treatment of depression: Findings from a clinical trial in nursing homes

Meeks

Ludwin

Looney

2016

Contemporary Clinical Trials Communications

Self Cite

View full text Add to dashboard Cite

Falls pose a significant health risk for nursing home residents and are associated with depression and medical treatments for depression. Data on falls as an adverse event to psychosocial treatments are lacking. We examined risk of falls as an adverse event in a clinical trial of a behavioral treatment for depression. Participants were 82 depressed nursing home residents. Adverse events were recorded at each research contact. We used the rate ratio based on the respective incidence densities in the treatment and control groups to measure association between fall rate and treatment. The treatment group had almost six times higher risk of falls than the control group, a statistically significant association. Findings suggest that it may be of value to include statistical analysis of falls as adverse events in trials of behavioral interventions for depression.

show abstract

Section: Resultsmentioning

confidence: 62%

Section: Methodsmentioning

confidence: 99%

mentioning

confidence: 99%

See 1 more Smart Citation

Falls as adverse events in psychosocial treatment of depression: Findings from a clinical trial in nursing homes

Meeks

Ludwin

Looney

2016

Contemporary Clinical Trials Communications

Self Cite

View full text Add to dashboard Cite

show abstract

“…This intervention model allows mental health professionals to be reimbursed for the ten individual sessions, and staff participation is encouraged with minimal collateral time in weekly consultation. This model was tested in a randomized clinical trial (see Meeks, Van Haitsma, Schoenbachler, & Looney, 2014 for a detailed description of this trial and primary outcomes). Twenty-four nursing homes participated in the clinical trial.…”

Section: Description Of Be-activ and The Clinical Trialmentioning

confidence: 99%

The BE-ACTIV Project: How Research, Professional Training, Education, and Practice Were Integrated in a Single Clinical Trial

Meeks

Getz

Hess

et al. 2015

Gerontology & Geriatrics Education

Self Cite

View full text Add to dashboard Cite

This paper describes how research, practice, and education were integrated in an NIMH-funded clinical trial for treating depression in nursing homes. Involving undergraduate and doctoral students in our clinical trial supported the development of key competencies, expanded the professional pipeline, and provided an avenue for disseminating the treatment to other settings. The clinical trial served as a teaching laboratory for sixteen undergraduate and six doctoral students to: (1) observe the culture of older adults in nursing homes, (2) develop and adapt clinical skills to a challenging patient population, (3) refine skills for collaborating in multidisciplinary teams, and (4) appreciate the relationship between science and practice. Dissemination of the intervention to non-research settings was served when the students took their skills to the settings where they launched their careers. Involvement of trainees in clinical trial research expands and enriches the capacity of the healthcare workforce in both evidence-based practice and practice-informed research.

show abstract

“…Most psychosocial interventions for depression in dementia, tested in randomized clinical trials, focus on older adults with depressive symptoms or milder non-diagnosed depression [15, 16]. Exceptions include a behavioral treatment for depression in dementia, which focuses on caregiver techniques to reduce depression in older adults with dementia and diagnosed minor or major depression [17] and a behavioral activities intervention for nursing home residents with dementia and a diagnosis of a depressive disorder [18]. However, the former treatment focuses mainly on patients with moderate to severe dementia, while the latter targets nursing home residents with varying degrees of depression.…”

Section: Introductionmentioning

confidence: 99%

Depression and Suicidal Ideation During Two Psychosocial Treatments in Older Adults with Major Depression and Dementia

Kiosses

Rosenberg

McGovern

et al. 2015

JAD

View full text Add to dashboard Cite

Background Depression is prevalent in dementia and contributes to poor outcomes for patients and their families. Antidepressants have limited efficacy in older adults with major depression and dementia and psychosocial interventions are under-investigated. Objective To examine the course and predictors of depression and suicidal ideation during 12 weeks of home-delivered Problem Adaptation Therapy (PATH) vs. Supportive Therapy for Cognitively Impaired Older Adults (ST-CI) in 39 older adults with major depression and dementia. Methods Thirty-nine older adults with major depression, mild or moderate dementia, and disability participated in an RCT that compared the efficacy of PATH versus ST-CI. Depression and suicidal ideation were assessed with Cornell Scale for Depression in Dementia (CSDD) Total Score and Suicide Item. Results PATH participants had significantly greater reduction in depression than ST-CI participants over 12 weeks of treatment. PATH participants with high social support had the greatest reduction in depression. Both treatments had comparable reduction in suicidal ideation. Conclusion PATH is more effective in reducing depression in older adults with major depression and dementia compared to ST-CI. These results are clinically significant as antidepressant medication treatments have limited efficacy in this population. Home-delivered psychosocial treatments may reduce suicidal ideation in this population.

show abstract

BE-ACTIV for Depression in Nursing Homes: Primary Outcomes of a Randomized Clinical Trial

Cited by 87 publications

References 39 publications

Falls as adverse events in psychosocial treatment of depression: Findings from a clinical trial in nursing homes

Falls as adverse events in psychosocial treatment of depression: Findings from a clinical trial in nursing homes

The BE-ACTIV Project: How Research, Professional Training, Education, and Practice Were Integrated in a Single Clinical Trial

Depression and Suicidal Ideation During Two Psychosocial Treatments in Older Adults with Major Depression and Dementia

Contact Info

Product

Resources

About