Beadex, a Drosophila LIM domain only protein, function in follicle cells is essential for egg development and fertility

Kairamkonda, Subhash; Nongthomba, Upendra

doi:10.1016/j.yexcr.2018.03.029

Experimental Cell Research

2018

DOI: 10.1016/j.yexcr.2018.03.029

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Beadex, a Drosophila LIM domain only protein, function in follicle cells is essential for egg development and fertility

Subhash Kairamkonda

Upendra Nongthomba

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2024

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Cited by 1 publication

References 54 publications

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The interplay between Zfh1 and Nau orchestrates the myogenic stage-dependent expression ofRbfox1and its targetStat92Evia amir-9a-mediated negative feedback loop inDrosophila melanogaster

Mukherjee,

Nongthomba

2024

Preprint

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RNA-binding Fox protein 1 (Rbfox1) controls gene expression at various levels: as a transcription co-factor, a splicing factor, and a regulator of mRNA stability and translation. Rbfox1 and its vertebrate orthologues have critical functions during development.Rbfox1mRNA, during adult myogenesis inDrosophila,exhibits bimodal expression, suggestive of the presence of a negative feedback loop. However, there are no known negative regulators ofRbfox1expression for this context. In this study, we show that the microRNAmir-9afunctions as a repressor ofRbfox1expression. Furthermore, the expression ofmir-9ais regulated by the expression of the identity transcription factor Nau. Nau and its targetmir-9aare expressed at mid myogenesis stage, and serve to restrict the expression ofRbfox1, and its targetsStat92Eandzfh1, to the early and the late myogenesis stages, as their ectopic expression is detrimental to early myofibrillogenesis. Zfh1, in turn, repressesmir-9aexpression, completing the feedback loop. Therefore, our findings identify the mechanism by which the temporal expression of the developmental geneRbfox1and its targets are tightly regulated, essential for their functions during myogenesis.Summary statementUsingDrosophila, we show that a microRNA-mediated negative feedback loop controls the expression of genes critical for skeletal muscle development.

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The interplay between Zfh1 and Nau orchestrates the myogenic stage-dependent expression ofRbfox1and its targetStat92Evia amir-9a-mediated negative feedback loop inDrosophila melanogaster

Mukherjee,

Nongthomba

2024

Preprint

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Beadex, a Drosophila LIM domain only protein, function in follicle cells is essential for egg development and fertility

Cited by 1 publication

References 54 publications

The interplay between Zfh1 and Nau orchestrates the myogenic stage-dependent expression ofRbfox1and its targetStat92Evia amir-9a-mediated negative feedback loop inDrosophila melanogaster

The interplay between Zfh1 and Nau orchestrates the myogenic stage-dependent expression ofRbfox1and its targetStat92Evia amir-9a-mediated negative feedback loop inDrosophila melanogaster

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