Beagle sciatic nerve regeneration across a 30 mm defect bridged by chitosan/PGA artificial nerve grafts

Ye, Peng; Li, Kaiyuan; Chen, Yufei; Li, Xiaojie; Zhu, Shu; Zhang, Zhengyu; Wang, Xiao; Duan, Li-na; Luo, Zhuojing; Du, Junjie; Wang, Jianchang

doi:10.1016/j.injury.2018.03.023

Cited by 26 publications

(21 citation statements)

References 13 publications

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“…Based on the results of the electrophysiological assessment, retrograde tracing as well as histological evaluation, this collagen-chitosan nerve scaffold presented results equivalent to the ANT. If further experimental research confirms these identical recovery results via artificial conduits, such strategies will next be investigated in future clinical trials (Peng et al, 2018).…”

Section: Experimental Chitosan-based Hybrid Strategies To Promote Permentioning

confidence: 99%

“…This led to superior results in histological and functional recovery compared to nerve conduits lacking an additional RGD sequence (Xiao et al, 2013). Recently, a collagen/chitosan nerve scaffold was introduced by Peng et al (2018) fabricated by an “unidirectional freezing process” followed by further freeze-drying (Ding et al, 2010). On the basis of a collagen and chitosan suspension, this new scaffold was applied for bridging a peripheral nerve defect of 30 mm of the beagle’s sciatic nerve.…”

Section: Experimental Chitosan-based Hybrid Strategies To Promote Permentioning

confidence: 99%

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Relevance and Recent Developments of Chitosan in Peripheral Nerve Surgery

Böcker

Daeschler

Kneser

et al. 2019

Front. Cell. Neurosci.

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Developments in tissue engineering yield biomaterials with different supporting strategies to promote nerve regeneration. One promising material is the naturally occurring chitin derivate chitosan. Chitosan has become increasingly important in various tissue engineering approaches for peripheral nerve reconstruction, as it has demonstrated its potential to interact with regeneration associated cells and the neural microenvironment, leading to improved axonal regeneration and less neuroma formation. Moreover, the physiological properties of its polysaccharide structure provide safe biodegradation behavior in the absence of negative side effects or toxic metabolites. Beneficial interactions with Schwann cells (SC), inducing differentiation of mesenchymal stromal cells to SC-like cells or creating supportive conditions during axonal recovery are only a small part of the effects of chitosan. As a result, an extensive body of literature addresses a variety of experimental strategies for the different types of nerve lesions. The different concepts include chitosan nanofibers, hydrogels, hollow nerve tubes, nerve conduits with an inner chitosan layer as well as hybrid architectures containing collagen or polyglycolic acid nerve conduits. Furthermore, various cell seeding concepts have been introduced in the preclinical setting. First translational concepts with hollow tubes following nerve surgery already transferred the promising experimental approach into clinical practice. However, conclusive analyses of the available data and the proposed impact on the recovery process following nerve surgery are currently lacking. This review aims to give an overview on the physiologic properties of chitosan, to evaluate its effect on peripheral nerve regeneration and discuss the future translation into clinical practice.

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Section: Experimental Chitosan-based Hybrid Strategies To Promote Permentioning

confidence: 99%

Section: Experimental Chitosan-based Hybrid Strategies To Promote Permentioning

confidence: 99%

Relevance and Recent Developments of Chitosan in Peripheral Nerve Surgery

Böcker

Daeschler

Kneser

et al. 2019

Front. Cell. Neurosci.

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show abstract

“…Furthermore, tremendous attention was directed towards clinically relevant artificial grafts, namely nerve guidance conduits that exhibit outstanding capacity to regenerate the injured peripheral nerves [74,75,76]. Herein, the current approaches consider acellular grafts (including membranes, meshes, scaffolds, tubes and gels) derived from ECM components [77,78,79,80,81] or new biomaterial-based architectures [82,83,84,85,86].…”

Section: Nervous System Regenerative Therapymentioning

confidence: 99%

Nanomaterial-Based Approaches for Neural Regeneration

Teleanu

Gherasim

Gherasim³

et al. 2019

Pharmaceutics

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Mechanical, thermal, chemical, or ischemic injury of the central or peripheral nervous system results in neuron loss, neurite damage, and/or neuronal dysfunction, almost always accompanied by sensorimotor impairment which alters the patient’s life quality. The regenerative strategies for the injured nervous system are currently limited and mainly allow partial functional recovery, so it is necessary to develop new and effective approaches for nervous tissue regenerative therapy. Nanomaterials based on inorganic or organic and composite or hybrid compounds with tunable physicochemical properties and functionality proved beneficial for the transport and delivery/release of various neuroregenerative-relevant biomolecules or cells. Within the following paragraphs, we will emphasize that nanomaterial-based strategies (including nanosized and nanostructured biomaterials) represent a promising alternative towards repairing and regenerating the injured nervous system.

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“…This led to superior results in histological and functional recovery compared to nerve conduits lacking an additional RGD sequence (Xiao et al, 2013). Recently, a collagen/chitosan nerve scaffold was introduced by Peng et al (2018) fabricated by an "unidirectional freezing process" followed by further freeze-drying (Ding et al, 2010). On the basis of a collagen and chitosan suspension, this new scaffold was applied for bridging a peripheral nerve defect of 30 mm of the beagle's sciatic nerve.…”

Section: Collagenmentioning

confidence: 99%

Peripheral Nerve Regeneration

Gambarotta¹,

Haastert‐Talini²,

Udina³

et al. 2019

Frontiers Research Topics

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Frontiers is more than just an open-access publisher of scholarly articles: it is a pioneering approach to the world of academia, radically improving the way scholarly research is managed. The grand vision of Frontiers is a world where all people have an equal opportunity to seek, share and generate knowledge. Frontiers provides immediate and permanent online open access to all its publications, but this alone is not enough to realize our grand goals. Frontiers Journal SeriesThe Frontiers Journal Series is a multi-tier and interdisciplinary set of open-access, online journals, promising a paradigm shift from the current review, selection and dissemination processes in academic publishing. All Frontiers journals are driven by researchers for researchers; therefore, they constitute a service to the scholarly community. At the same time, the Frontiers Journal Series operates on a revolutionary invention, the tiered publishing system, initially addressing specific communities of scholars, and gradually climbing up to broader public understanding, thus serving the interests of the lay society, too. Dedication to QualityEach Frontiers article is a landmark of the highest quality, thanks to genuinely collaborative interactions between authors and review editors, who include some of the world's best academicians. Research must be certified by peers before entering a stream of knowledge that may eventually reach the public -and shape society; therefore, Frontiers only applies the most rigorous and unbiased reviews. Frontiers revolutionizes research publishing by freely delivering the most outstanding research, evaluated with no bias from both the academic and social point of view. By applying the most advanced information technologies, Frontiers is catapulting scholarly publishing into a new generation. What are Frontiers Research Topics?Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject.

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Beagle sciatic nerve regeneration across a 30 mm defect bridged by chitosan/PGA artificial nerve grafts

Cited by 26 publications

References 13 publications

Relevance and Recent Developments of Chitosan in Peripheral Nerve Surgery

Relevance and Recent Developments of Chitosan in Peripheral Nerve Surgery

Nanomaterial-Based Approaches for Neural Regeneration

Peripheral Nerve Regeneration

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Beagle sciatic nerve regeneration across a 30 mm defect bridged by chitosan/PGA artificial nerve grafts

Cited by 26 publications

References 13 publications

Relevance and Recent Developments of Chitosan in Peripheral Nerve Surgery

Relevance and Recent Developments of Chitosan in Peripheral Nerve Surgery

Nanomaterial-Based Approaches for Neural Regeneration

Peripheral Nerve Regeneration

Contact Info

Product

Resources

About

Beagle sciatic nerve regeneration across a 30 mm defect bridged by chitosan/PGA artificial nerve grafts