Beam Hardening Correction with an Iterative Scheme Using an Exact Backward Projector and a Polychromatic Forward Projector

Bock, Rüdiger; Hoppe, S.; Scherl, Holger; Hornegger, Joachim

doi:10.1007/978-3-540-71091-2_10

Cited by 1 publication

(1 citation statement)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The principal artifact, beam hardening effect, leads to variations of grey level with the size of sample [3]. Different method are available for beam hardening correction [4,5,6,7]. After correction, the relation between grey level and densities could be calibrated by a linear approximation [8,9].…”

Section: Calibration Of Grey Levelsmentioning

confidence: 99%

3D visualization and quantification of bone and teeth mineralization for the study of osteo/dentinogenesis in mice models

Marchadier

Vidal

Ordureau³

et al. 2011

Medical Imaging 2011: Biomedical Applications in Molecular, Structural, and Functional Imaging

View full text Add to dashboard Cite

Research on bone and teeth mineralization in animal models is critical for understanding human pathologies. Genetically modified mice represent highly valuable models for the study of osteo/dentinogenesis defects and osteoporosis. Current investigations on mice dental and skeletal phenotype use destructive and time consuming methods such as histology and scanning microscopy. Micro-CT imaging is quicker and provides high resolution qualitative phenotypic description. However reliable quantification of mineralization processes in mouse bone and teeth are still lacking. We have established novel CT imaging-based software for accurate qualitative and quantitative analysis of mouse mandibular bone and molars.Data were obtained from mandibles of mice lacking the Fibromodulin gene which is involved in mineralization processes. Mandibles were imaged with a micro-CT originally devoted to industrial applications (Viscom, X8060 NDT). 3D advanced visualization was performed using the VoxBox software (UsefulProgress) with ray casting algorithms. Comparison between control and defective mice mandibles was made by applying the same transfer function for each 3D data, thus allowing to detect shape, colour and density discrepencies. The 2D images of transverse slices of mandible and teeth were similar and even more accurate than those obtained with scanning electron microscopy. Image processing of the molars allowed the 3D reconstruction of the pulp chamber, providing a unique tool for the quantitative evaluation of dentinogenesis.This new method is highly powerful for the study of oro-facial mineralizations defects in mice models, complementary and even competitive to current histological and scanning microscopy appoaches.

show abstract