Beamforming Design for High-Resolution Low-Intensity Focused Ultrasound Neuromodulation

Fan, Boqiang; Goodman, Wayne K.; Cho, Raymond Y.; Sheth, Sameer A.; Bouchard, Richard R.; Aazhang, Behnaam

doi:10.1109/icassp40776.2020.9054234

ICASSP 2020 - 2020 IEEE International Conference on Acoustics, Speech and Signal Processing (ICASSP) 2020

DOI: 10.1109/icassp40776.2020.9054234

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Beamforming Design for High-Resolution Low-Intensity Focused Ultrasound Neuromodulation

Boqiang Fan

Wayne K. Goodman

Raymond Y. Cho

et al.

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2023

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Cited by 1 publication

References 39 publications

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Computational modeling and minimization of unintended neuronal excitation in a LIFU stimulation

Fan,

Goodman,

Cho

et al. 2023

Sci Rep

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The neuromodulation effect of low-intensity focused ultrasound (LIFU) is highly target-specific. Unintended off-target neuronal excitation can be elicited when the beam focusing accuracy and resolution are limited, whereas the resulted side effect has not been evaluated quantitatively. There is also a lack of methods addressing the minimization of such side effects. Therefore, this work introduces a computational model of unintended neuronal excitation during LIFU neuromodulation, which evaluates the off-target activation area (OTAA) by integrating an ultrasound field model with the neuronal spiking model. In addition, a phased array beam focusing scheme called constrained optimal resolution beamforming (CORB) is proposed to minimize the off-target neuronal excitation area while ensuring effective stimulation in the target brain region. A lower bound of the OTAA is analytically approximated in a simplified homogeneous medium, which could guide the selection of transducer parameters such as aperture size and operating frequency. Simulations in a human head model using three transducer setups show that CORB markedly reduces the OTAA compared with two benchmark beam focusing methods. The high neuromodulation resolution demonstrates the capability of LIFU to effectively limit the side effects during neuromodulation, allowing future clinical applications such as treatment of neuropsychiatric disorders.

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Computational modeling and minimization of unintended neuronal excitation in a LIFU stimulation

Fan,

Goodman,

Cho

et al. 2023

Sci Rep

View full text Add to dashboard Cite

show abstract

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Beamforming Design for High-Resolution Low-Intensity Focused Ultrasound Neuromodulation

Cited by 1 publication

References 39 publications

Computational modeling and minimization of unintended neuronal excitation in a LIFU stimulation

Computational modeling and minimization of unintended neuronal excitation in a LIFU stimulation

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