In this paper, a static load test and a multiparameter statistical analysis method are used to study the value of pile side friction in different soil layers in a loess region. Currently, static load testing is the most commonly used method to determine the bearing capacity of pile foundation. During the test, a vertical load is applied at the top of the pile, the data under each load level are recorded, and a Q-S curve is drawn to obtain the ultimate bearing capacity of a single pile. Reinforcement stress gauges are installed at different sections of the pile body, and then the axial force and the pile side friction of each section are calculated. Few studies have investigated the calculation of pile side friction in different soil layers using the multiparameter statistical analysis method. Obtaining accurate results using this method will provide an important supplement to the calculation of pile side friction and will also be conducive to the development of theoretical calculation of pile side friction. Therefore, taking Wuding Expressway project in loess region as an example, the lateral friction resistance of six test piles is studied through static load testing and multiparameter statistical analysis. The multiparameter statistical analysis method is compared with the static load test results, and the error is controlled within 20%. The results show that the calculation results of multiparameter statistical analysis essentially fulfill engineering requirements.