Beauvericin, a Bioactive Compound Produced by Fungi: A Short Review

Wang, Qinggui; Xu, Luping

doi:10.3390/molecules17032367

Cited by 225 publications

(169 citation statements)

References 44 publications

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“…The biometabolite beauvericin is first isolated from liquid fermented culture of Beaveria bassiana, which is a common and commercial entomopathogenic mycoinsecticide [6,7]. The genus Beauveria is well known mycoinsecticide and exhibits antimicrobial, antitumor, antifungal and antiviral activities [8]. The entomopathogenic fungus, Beauveria bassiana belongs to Phylum Ascomycota.…”

Section: Introductionmentioning

confidence: 99%

“…It was found that BEA targets the cell organelles such as ribosomes or cell nucleus and enzymes, as BEA is synthesized from amino acids. Unlike other antibiotics example as penicillin which blocks the peptidoglycan biosynthesis of Gram-positive bacteria whose cell wall is not the antibacterial mode of action of beauvericin, although these antibiotics and beauvericin are both from amino acids that are produced by fungi [8]. Bacterial strains which are inhibited by BEA are listed in Table 1.…”

Section: Antimicrobial Activitymentioning

confidence: 99%

“…Wang and Xu reviewed the biosynthesis of bioactive secondary metabolite beauvericin [8]. A multifunctional enzyme beauvericin synthetase with a molecular mass of 250 kDa helps in the synthesis of BEA [24].…”

Section: Biosynthesis Of Beauvericinmentioning

confidence: 99%

“…Among peptone and NaNO 3 , peptone is the major source of nitrogen [33,34]. Being an intracellular product, only a small amount of BEA is exported into the medium [8,35]. Xu studied F. redolens Dzf2 mycelial culture along with macroporous polystyrene resin as sorbent increases the production of BEA from 194-265 mg/L.…”

Section: Biosynthesis Of Beauvericinmentioning

confidence: 99%

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Pharmacological and Therapeutic Potential of Beauvericin: A Short Review

Sood¹,

S²,

Hu$^{³

et al. 2017

J Proteomics Bioinform

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An entomopathogenic fungus, Beauveria spp. has been known to have numerous pharmacological and therapeutic implications, especially, in terms of human health making it a suitable for ethnopharmacological use. Beauvericin is a cyclic hexadepsipeptide mycotoxin, a novel bio-metabolite derived from this fungus, exhibiting a very potent anticancer, cytotoxic activities, antiplatelet aggregation and antimicrobial activities. The current review discusses the therapeutic potential of beauvericin including pharmacological and biological activities which will certainly draw the attention of scientific community to improve the production of beauvericin for its use in medical fields.

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Section: Introductionmentioning

confidence: 99%

Section: Antimicrobial Activitymentioning

confidence: 99%

Section: Biosynthesis Of Beauvericinmentioning

confidence: 99%

Section: Biosynthesis Of Beauvericinmentioning

confidence: 99%

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Pharmacological and Therapeutic Potential of Beauvericin: A Short Review

Sood¹,

S²,

Hu$^{³

et al. 2017

J Proteomics Bioinform

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“…The cyclodepsipeptides have shown insecticidal activity against several species, such as fifth instar larvae of the silkworm Bombyx mori, 9 Calliphora erythrocephala, Aedes aegypti, Lygus spp., Spodoptera frugiperda, Schizaphis graminum 47 and Sitophilus spp. 48 However, the mycelium and conidia of a B. bassiana strain, pathogenic to Tribolium castaneum and Sitophilus oryzae, showed no toxicity against rats and mice.…”

Section: Larvicidal Activitymentioning

confidence: 99%

Larvicidal Activity of Beauveria bassiana Extracts against Aedes aegypti and Identification of Beauvericins

Daniel

Silva

Nakagawa

et al. 2016

J. Braz. Chem. Soc.

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Beauveria bassiana is an entomopathogenic fungus that has been well known for its capacity to act as biopesticide on various disease vectors. The analysis of organic extracts of strains CG71 and UNI40 led to identification of cyclodepsipeptides beauvericin, beauvericin A or F, beauvericin E and bassianolide by ultra-high pressure liquid chromatography-high resolution mass spectrometry in tandem mode (UHPLC-HRMS/MS). The larvicidal activity on 3 rd instar of Aedes aegypti revealed LC 50 0.9887 and 0.4653 ppm in 24 and 48 hours (CG71 methanolic extract), LC 50 0.7834 ppm in 48 hours (CG71 ethyl acetate), LC 50 0.7834 and 1.8149 ppm (UNI 40 for ethyl acetate and methanolic extracts, respectively) in 48 hours. These findings highlight the potential of B. bassiana metabolites for controlling the vector of Dengue and Zika diseases. Keywords: cyclohexadepsipeptides, Dengue, Zika, beauvericins, UHPLC-HRMS/MS IntroductionThe entomopathogenic Beauveria bassiana has a broad host range naturally attacking insects and variety of arthropod species. [1][2][3] Due to this ability, it is used as a biopesticide agent on diverse disease vectors, including crop pests, ticks and mosquitoes. 4,5 The attack on insect cuticle occurs after hyphae of B. bassiana penetrate the insect integument by enzymatic action. 6 Species of entomopathogenic fungi have been described as producers of secondary metabolites, including bioactive non-ribosomal peptides and polyketides. 7 B. bassiana produces the cyclooligomer nonribosomal depsipeptides beauvericins and bassianolide, 8,9 beauveriolides, 10 D, E and F. 25 Bassianolide is another cyclooctadepsipeptide metabolite produced B. bassiana and Lecanicillium lecanii. 9 It is toxic to insects and probably also acts as an ionophore, such as other cyclodepsipeptides. 15 The structural diversity of metabolites from entomopathogenic fungi, associated with diverse biological activities, stimulates the research by on bioactive fungal extracts for controlling insect pests and disease vectors.Larvicidal Activity of Beauveria bassiana Extracts against Aedes aegypti and Identification of Beauvericins J. Braz. Chem. Soc. 1004 Dengue is a viral infection transmitted to humans by Aedes aegypti mosquitoes that became a major concern of the public health sector. 26 There were 96 million apparent dengue infections globally in 2010, of which the Americas contributed 14% (13 million infections) of worldwide and over half developed in Brazil and Mexico. 27 Due to no effective antiviral agents and licensed vaccine for infection, the decrease in transmission depends only on vector control by elimination of artificial and disposable water inundated larvae breeding sites and application of insecticides. 27,28 Furthermore, studies reveal resistance in the vector population to various substances, in Brazil there is an irregular distribution of insecticide resistance. 28 Furthermore, Aedes mosquitoes also transmit Zika virus; attracting worldwide attention in 2016, when the vector caused widespread epidemic cases in Braz...

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