Beauverolides L and La from Beauveria tenella and Paecilomyces fumosoroseus

Jegorov, Alexandr; Sedmera, Petr; Matha, V.; Šimek, Petr; Zahradníčková, Helena; Landa, Z.; Eyal, J.

doi:10.1016/s0031-9422(00)90402-3

Cited by 47 publications

(38 citation statements)

References 10 publications

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“…In contrast, Champlin and Grula (1979) reported that beauvericin was not toxic to Helicoverpa zea Boddie and that bassianolide caused temporary atony. Paecilomyces fumosoroseus (Wize) Brown & Smith (=Isaria fumosorosea) has also been reported to produce beauvericin (Bernardini et al, 1975) and beauverolides (Jegorov et al, 1994), and Verticillium lecanii (=Lecanicillium lecanii) also produces bassionalide (Suzuki et al, 1977). Other entomopathogenic fungi also produce metabolites, e.g., Isaria spp.…”

Section: Discussionmentioning

confidence: 99%

Entomopathogenic fungal endophytes

Vega¹,

Posada²,

Aime³

et al. 2008

Biological Control

444

238

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Fungal endophytes are quite common in nature and some of them have been shown to have adverse effects against insects, nematodes, and plant pathogens.Our research program is aimed at using fungal endophytes-mediated plant defense as a novel biological control mechanism against the coffee berry borer, the most devastating pest of coffee throughout the world. A survey of fungal endophytes in coffee plants from Hawaii, Colombia, Mexico, and Puerto Rico has revealed the presence of various genera of fungal entomopathogens, including Acremonium, Beauveria, Cladosporium, Clonostachys, and Paecilomyces. Two of these, B. bassiana and Clonostachys rosea, were tested against the coffee berry borer and were shown to be pathogenic. This paper reviews the possible mode of action of entomopathogenic fungal endophytes. Published by Elsevier Inc.

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Section: Discussionmentioning

confidence: 99%

Entomopathogenic fungal endophytes

Vega¹,

Posada²,

Aime³

et al. 2008

Biological Control

444

238

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“…was used (Macherey Nagel, Düren, Germany). Beauverolides were separated at a flow rate of 400 µl min 1 , with an acetonitrile gradient [water (A), acetonitrile (B), both containing 1% acetic acid] over 40 min.…”

Section: Hplcmentioning

confidence: 99%

“…Beauverolides are produced by the microorganisms Beauveria bassiana, Beauveria brogniartii, Beauveria vermicoria and Paecilomyces fumosoroseus. 1,2 These fungi possess the ability to produce infectious conidia, which can germinate and penetrate the insect cuticle when attached to their host. B. bassiana, B. brogniartii, and P. fumosoroseus have been shown to be effective entomopathogens and were developed for use as mycoinsecticidal agents for the control of Colorado potato beetle 3,4 Leptinotarsa decemlineata, 5 grasshoppers, 6 aphids, 7 or sweet potato whitefly, Bemisia tabaci.…”

Section: Introductionmentioning

confidence: 99%

“…Up to now, only electron ionization (EI) mass spectra of beauverolides have been reported 1,18,19 (Table 1). Although the accurate EI mass spectral data have revealed detailed information on structures of pure substances, no useful information can be obtained with this technique when applied in complex mixture analysis.…”

Section: Introductionmentioning

confidence: 99%

“…Purification was carried out by preparative HPLC as described originally elsewhere. 1 Alternatively, some beauverolides were separated from the crude mixture by sublimation carried out at ¾180°C (5 Pa). (Phe, C-ipso), 128.8 (Phe, C-ortho), 128.0 (Phe, C-meta), 126.2 (Phe, C-para ), 75.4 (C 9 , 3ˇ), 56.4 (Phe, C-˛), 51.8 (Leu, C-˛), 48.3 (Ala, C-˛), 40.5 (Leu, C-ˇ), 35.3 (Phe, C-ˇ), 35.3 (C 9 , C-˛), 34.7 (C 9 , C-), 30.3 (C 9 , C-υ), 28.6 (C 9 , C-ε), 24.1 (Leu, C-), 22.2 (C 9 , C-), 22.1 (Leu, C-υ 1 ), 21.6 (Leu, C-υ 2 ), 15.2 (Ala, C-ˇ), 15.1 (C 9 , CH 3 -), 13.6 (C 9 , C-Á).…”

Section: Introductionmentioning

confidence: 99%

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Sequencing of new beauverolides by high‐performance liquid chromatography and mass spectrometry

Kuzma

Jegorov²,

Kačer

et al. 2001

J. Mass Spectrom.

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Mass spectrometry (MS) and tandem mass spectrometry (MS(n)) were used for the identification of beauverolides in the fermentation broth of Beauveria bassiana and for evaluation of the purified fraction obtained by sublimation of beauverolides. Besides being a new efficient route for purification of beauverolides, sublimation provided an enrichment of new minor lipophilic beauverolides of lower molecular weight from the original complex mycelial extract. The product ion collision-induced dissociation (CID) spectra obtained on an ion trap (electrospray ionization), the in-source CID mass spectra on a sector instrument (atmospheric-pressure chemical ionization) and the post-source decay matrix-assisted laser desorption/ionization mass spectra of beauverolides were compared and evaluated. All MS(n) experiments started with singly charged precursor ions. The following two new representatives of this group of compounds were identified by high-performance liquid chromatography and MS (HPLC/MS): cyclo-(3-hydroxy-4-methyloctanoyl-valyl-alanyl-leucyl) and cyclo-(3-hydroxy-4-methyloctanoyl-tyrosyl-alanyl-leucyl). Individual structures were confirmed by preparative isolation and nuclear magnetic resonance spectroscopy. The structure of a third novel and minor beauverolide was tentatively assigned by HPLC/MS only as cyclo-(3-hydroxy-4-methyldecanoyl-valyl-alanyl-Lxx), Lxx = leucyl, isoleucyl, or allo-isoleucyl.

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Microbial Source of Insect‐Toxic Proteins

Yadav

Mishra

2021

Bioprospecting of Microorganism‐Based Industrial Molecules

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Beauverolides L and La from Beauveria tenella and Paecilomyces fumosoroseus

Cited by 47 publications

References 10 publications

Entomopathogenic fungal endophytes

Entomopathogenic fungal endophytes

Sequencing of new beauverolides by high‐performance liquid chromatography and mass spectrometry

Microbial Source of Insect‐Toxic Proteins

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