Becker’s Nevus Syndrome in a Pediatric Female Patient

Hernandez-Quiceno, Sara; Uribe-Bojanini, Esteban; Ramírez-Jiménez, Juan Jose; Lopera-Cañaveral, Maria Victoria; Toro-Ramos, Martín; Usuga-Arcila, Yuri; Correa-Londoño, Luis Alfonso; Martínez, Juan Camilo; Monroy, Jennifer Marie; Alfaro, Juan Manuel Esquivel

doi:10.1155/2016/3856518

Cited by 5 publications

(5 citation statements)

References 13 publications

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“…The diagnosis is also supported by histology finding of high levels of androgen receptors in the hypoplastic muscles comparable to the levels expressed at the genitals. Biopsy of the skin lesion revealed an increase in the number of smooth muscle bundles, hair follicles, and enlarged papillary crests with pigmentation in basal epidermis [6] .…”

Section: Discussionmentioning

confidence: 99%

Becker’s nevus syndrome: a case report

2021

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Background Becker’s nevus syndrome is a syndrome characterized by the presence of a Becker’s nevus with ipsilateral breast hypoplasia or hypoplastic defects of the muscle, skin, or skeleton. The nevus usually consists of a circumscribed, unilateral, irregularly shaped hyperpigmented macule, commonly occurring around the anterior upper trunk, with/without hypertrichosis and/or acneiform lesions. This rare syndrome has not been reported in our locality to the best of our knowledge. Case presentation We report the case of a 15-year-old Igbo female patient who presented to our pediatric endocrinology clinic, University of Nigeria Teaching Hospital, Enugu, with complaints of asymmetry of the breasts and hyperpigmented macules on the side. Based on her symptoms, diagnosis of Becker’s nevus syndrome was made. The diagnosis of Becker’s nevus syndrome is mostly clinical, based on the presence of a Becker’s nevus with ipsilateral breast hypoplasia or hypoplastic defects of the muscle, skin, or skeleton. In our patient, there was a Becker’s nevus with ipsilateral breast hypoplasia. This syndrome, belonging to the class of epidermal nevus syndromes, is very rare, and is usually benign. She was placed on spironolactone tablets 50 mg daily, which have been associated with an improvement in the size of the hypoplastic breast, and her fears were allayed. Conclusion This syndrome has not been reported in our locality to the best of our knowledge and, therefore, has a propensity for misdiagnosis by clinicians because of its rarity. We therefore report this to create awareness among clinicians regarding this condition that is associated with much psychosocial trauma among patients, and that can be easily managed with oral spironolactone.

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Section: Discussionmentioning

confidence: 99%

Becker’s nevus syndrome: a case report

2021

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“…This syndrome has been thought to be a hormone-dependent disorder because the overexpression of androgen receptors in the Becker's nevus area has been detected [8]. Since androgens also affect hair, muscle, and bone development, this syndrome may be related to the pathogenesis of other systemic manifestations [14].…”

Section: Discussionmentioning

confidence: 99%

“…Several studies have reported the relationship between Becker's nevus and other developmental anomalies [11,12]. In 1997, Happle and Koopman suggested a new term of "Becker's nevus syndrome" for the simultaneous presence of a Becker's nevus and other cutaneous, muscular, or skeletal defects, such as hypoplasia of the breast or scoliosis [13,14]. Most of these anomalies tend to coincide with the nevus sites and are mostly ipsilateral [15].…”

Section: Introductionmentioning

confidence: 99%

Comprehensive Treatment of a Skeletal Class III Growing Patient with Alveolar Bone Hypertrophy in the Anterior Mandible Associated with Becker’s Nevus Syndrome: A Case Report

Baik

Choi

2021

Children

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Becker’s nevus is a relatively common skin lesion with brown hyperpigmentation and hypertrichosis. It may be expressed simultaneously with other cutaneous, muscular, or skeletal defects, such as hypoplasia of the breast or scoliosis, for which the term “Becker’s nevus syndrome” has been proposed. An 8-year-old boy presented with a Becker’s nevus on the right cheek, chin, and upper neck with alveolar bone hypertrophy in the anterior mandible, which led to an anterior crossbite and severe canting of the mandibular anterior teeth. Through orthopedic treatment using a face mask, the anteroposterior jaw relationship was improved. In phase 2 treatment, we corrected the canting of the mandibular anterior teeth with a segmental intrusion of the mandibular anterior right teeth into the hypertrophic alveolar bone area. The facial profile was improved along with acceptable occlusion, and the treatment result was stable at 1 year after the end of the treatment, without any periodontal attachment loss, root resorption of mandibular anterior teeth, or increase in the size of the hypertrophic region. This case report describes the successful comprehensive treatment of a growing patient with skeletal Class III malocclusion and multiple characteristics of Becker’s nevus syndrome.

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“…Pigmented patches on exposed areas cause cosmetic concerns, thus warranting medical intervention. Several therapeutic options, including cryotherapy, dermabrasion, surgical excision, oral antiandrogens, and topical glycolic acid, have been proposed [3][4][5]. Laser therapy for BN has recently become increasingly popular.…”

Section: Introductionmentioning

confidence: 99%

A Retrospective Analysis of the Efficacy and Safety of Q‐Switched and Picosecond Lasers for Treating Becker’s Nevus

Liu

Jia

Gong

et al. 2023

Dermatologic Therapy

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Background. Becker’s nevus (BN) severely affects a patient’s appearance and can lead to depression, especially when it involves the face or neck. Currently, there is no effective treatment. Laser therapy has become popular, but its efficacy has not been confirmed. We evaluated the efficacy and safety of lasers in treating BN. Methods. This retrospective study involved 49 patients exposed to different laser treatments who completed at least one treatment session and follow-up. Results. The patients treated with the 755-nm alexandrite picosecond laser and Q-switched 694-nm ruby laser gained relatively good results: 3.07 ± 1.09 and 2.87 ± 1.14 on the five-point scale and 3.47 ± 0.73 and 3.40 ± 0.85 on the GAIS, respectively. However, the results of the 755-nm alexandrite picosecond laser with a diffractive focus lens array and the fractionated 1064-nm neodymium-doped: yttrium aluminum garnet picosecond laser were poor. Furthermore, there were marked differences between the number of treatment sessions and treatment effects, both for the five-point grading score for pigment clearance (F = 15.246, p < 0.001 ) and GAIS (F = 15.469, p < 0.001 ). Concerning different lasers and efficacy, there were no marked differences between the five-point grading scale and the GAIS ( p > 0.05 ). Conclusions. Although the efficacy of various lasers for BN is not satisfactory and there are no marked differences between picosecond and Q-switched lasers, they can help in selecting an appropriate laser for slight-to -moderate pigment removal. The 755-nm alexandrite picosecond laser is a new option, whereas nonablative fractional picosecond lasers for BN are not recommended. Increasing the number of treatment sessions can improve the curative effect slightly.

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Becker’s Nevus Syndrome in a Pediatric Female Patient

Cited by 5 publications

References 13 publications

Becker’s nevus syndrome: a case report

Becker’s nevus syndrome: a case report

Comprehensive Treatment of a Skeletal Class III Growing Patient with Alveolar Bone Hypertrophy in the Anterior Mandible Associated with Becker’s Nevus Syndrome: A Case Report

A Retrospective Analysis of the Efficacy and Safety of Q‐Switched and Picosecond Lasers for Treating Becker’s Nevus

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