Beclin1-associated complex in autophagy and regulation

Behura, Assirbad; Dhiman, Rohan

doi:10.1016/b978-0-323-90142-0.00004-9

Autophagy Processes and Mechanisms 2024

DOI: 10.1016/b978-0-323-90142-0.00004-9

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Beclin1-associated complex in autophagy and regulation

Assirbad Behura,

Rohan Dhiman

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2024

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Cited by 1 publication

References 131 publications

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RhoBTB3 Functions as a Novel Regulator of Autophagy by Suppressing AMBRA1 Stability

Kim,

Kim

2024

Cells

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Autophagy is essential for cell survival and cellular homeostasis under various stress conditions. Therefore, autophagy dysfunction is associated with the pathogenesis of various human diseases. We explored the regulatory role of RhoBTB3 in autophagy and its interaction with activating molecules in AMBRA1. RhoBTB3 deficiency was found to induce autophagy, while its overexpression inhibited autophagy induction. Through immunoprecipitation and mass spectrometry, AMBRA1 was identified as a substrate of RhoBTB3. The study revealed that RhoBTB3 regulates AMBRA1 stability by influencing its protein levels without affecting its mRNA levels. RhoBTB3 induced the ubiquitination of AMBRA1, leading to proteasome-mediated degradation, with the ubiquitination occurring at K45 on AMBRA1 through a K27-linked ubiquitin chain. The knockdown of AMBRA1 blocked RhoBTB3 knockdown-induced autophagy, indicating the dependency of autophagy on AMBRA1. Thus, RhoBTB3 negatively regulates autophagy by mediating AMBRA1 ubiquitination and degradation, suggesting RhoBTB3 as a potential therapeutic target for autophagy-related diseases.

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RhoBTB3 Functions as a Novel Regulator of Autophagy by Suppressing AMBRA1 Stability

Kim,

Kim

2024

Cells

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Beclin1-associated complex in autophagy and regulation

Cited by 1 publication

References 131 publications

RhoBTB3 Functions as a Novel Regulator of Autophagy by Suppressing AMBRA1 Stability

RhoBTB3 Functions as a Novel Regulator of Autophagy by Suppressing AMBRA1 Stability

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