Beclomethasone Dipropionate: A New Steroid Aerosol for the Treatment of Allergic Asthma

Brown, H. Morrow; Storey, G. C. A.; George, W. H. S.

doi:10.1136/bmj.1.5800.585

Cited by 322 publications

(83 citation statements)

References 16 publications

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“…The authors observed that the patients who did best had high numbers of eosinophils in their sputum [102]. This observation has been confirmed in other subsequent studies and the use of inhaled corticosteroids in asthma has been the major reason why asthma morbidity and mortality have fallen [103].…”

Section: Corticosteroidsmentioning

confidence: 58%

Allergic Asthma and Aging

Lorenzo¹,

Bona²,

Piana³

et al. 2012

Bronchial Asthma - Emerging Therapeutic Strategies

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Section: Corticosteroidsmentioning

confidence: 58%

Allergic Asthma and Aging

Lorenzo¹,

Bona²,

Piana³

et al. 2012

Bronchial Asthma - Emerging Therapeutic Strategies

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“…In our initial studies (Brown et al, 1972) corticosteroids were withdrawn too quickly. Our present practice is to transfer the patients to 1-mg prednisolone tablets, equivalent to their usual total daily maintenance dose, and then to reduce the dose by 1 mg daily with regular PFM monitoring.…”

Section: Methods Oftransfermentioning

confidence: 99%

“…Since our first clinical trial was published (Brown et al, 1972), many other investigators have confirmed that beclomethasone dipropionate aerosol (BDA) is effective in the control of asthma. We have confirmed our original findings in children with seasonal asthma and hay fever, and have reported our long-term experience in the treatment of perennial and seasonal asthma, and also allergic rhinitis (Brown & Storey, 1973Brown et al, 1977).…”

Section: Introductionmentioning

confidence: 99%

Beclomethasone dipropionate aerosol in long‐term treatment of perennial and seasonal asthma in children and adults: a report of five‐and‐half years' experience in 600 asthmatic patients.

Brown¹,

Storey²,

Jackson³

1977

Brit J Clinical Pharma

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Derby DE1 1RX,UK I Clinical experience in the long-term treatment of allergic asthma with beclomethasone dipropionate aerosol (BDA) during the past five-and-half years is reviewed. A total of 600 patients from National Health Service and private practice, including 176 children, was treated. 2 A total of 241 patients, including 57 children, was corticosteroid-dependent for 1-18 yr. Of these patients, 70% were successfully transferred to BDA, 21% could be only partially transferred, and 9% could not. Over the years, 12% had to revert to oral corticosteroids, but 4% were able to stop BDA without relapse. Oropharyngeal thrush was observed in 16%, but in only two cases did treatment have to be withdrawn on that account. There were no deaths from asthma, and seven normal births. 3 A total of 359 non-corticosteroid-dependent asthmatics, including 119 children, were also treated with BDA. Successful control of symptoms was achieved in 99%, but 4% eventually became corticosteroid-dependent. There were three deaths from asthma and 13 normal births. Fifteen per cent were able to stop treatment without relapse. Five per cent developed oropharyngeal candidiasis, but treatment did not have to be stopped on that account. 4 In 35% of both groups, a preliminary course of oral corticosteroid at high dosage was required before the introduction of BDA therapy. Sixty-two patients were treated for over 5 yr, and approximately 1350 patient-years of BDA have been given without evidence of side-effects. S Thirty-one corticosteroid-dependent and 73 non-corticosteroid dependent patients with perennial asthma had 231 seasonal episodes, effectively controlled in 68%, and 38 purely seasonal asthmatics had 100 episodes, with good control in 80% of cases.

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“…The first clinical trial of albuterol was reported in 1969 (38). It was not until the mid-1970s that "safe" inhaled steroid preparations began to become available (39). Highly atopic children were treated by pediatric allergists, but children with asthma by and large continued to be treated by family practitioners and pediatricians rather than allergists or pulmonologists.…”

Section: Early Development Of Pediatric Pulmonologymentioning

confidence: 99%

Pediatric Pulmonology: A Developmental History in North America

Chernick

Mellins

2004

Pediatr Res

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We describe the development of pediatric pulmonology in North America, from its rudimentary beginning in the early part of the 20th century. Milestones in the history of lung diseases affecting children, such as tuberculosis, cystic fibrosis, asthma, and neonatal lung disease, are discussed. Finally, maturation into a subspecialty recognized by the American Board of Pediatrics is described. An understanding of the function of the respiratory system and descriptions of disorders that affect the lung date back to antiquity. This historical perspective of the discipline of pediatric pulmonology begins in the 1800s. At the end of the 19th century, when the American Pediatric Society (APS) was formed, the main scourges of children were infectious diseases, including diarrhea, diphtheria, tuberculosis, scarlet fever, pneumonia and empyema, typhoid fever, influenza, and "hereditary" syphilis (1). Concepts of public hygiene, proper diet, and fluid replacement therapy were rudimentary or absent. The only laboratory tools available were pathologic histology and morphologic bacteriology. Notably, only two of the 43 founding members of the APS limited their practice to pediatrics: L. Emmett Holt (New York) and Isaac Love (St. Louis) (2).The following is a very truncated view of some of the APS meetings and the topics discussed that pertained to pulmonology. The first meeting of the APS was held in 1889 in Washington, DC, and was attended by 25 members who read 27 papers (1). Many of the papers were devoted to infant feeding, but there were presentations on pneumothorax and lung expansion, tuberculosis, meningitis, scarlet fever, neona-

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Beclomethasone Dipropionate: A New Steroid Aerosol for the Treatment of Allergic Asthma

Cited by 322 publications

References 16 publications

Allergic Asthma and Aging

Allergic Asthma and Aging

Beclomethasone dipropionate aerosol in long‐term treatment of perennial and seasonal asthma in children and adults: a report of five‐and‐half years' experience in 600 asthmatic patients.

Pediatric Pulmonology: A Developmental History in North America

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