“…It is also important to note that the population estimates (for AD) highlighted above do not include individuals with related (potentially treatable) conditions such as “Mild Cognitive Impairment” (MCI) which is characterized by a less severe (but abnormal) level of cognitive impairment (reviewed Petersen et al, 2004) and a high-risk for developing dementia (reviewed, Luck et al, 2010). Even in the absence of a diagnosable disorder of cognition (e.g., AD, MCI), the perception of increased forgetfulness and declining memory function is a clear source of distress, embarrassment, and low self esteem in the elderly (Imhof et al, 2006; Ohman et al, 2008, see also review, Ballard, 2010). Undoubtedly these factors have (at least in part) driven sales of over the counter nutritional supplements (e.g., ginko biloba, phosphatidyl serine) that promise improved memory function (now a billion dollar industry in the United States alone), despite the lack of any clear evidence of their effectiveness (Kennedy, 2004, see also review, Lanni et al, 2008).…”