Adding to the growing body of literature on outcomes for children living in orphanages and children's homes, this qualitative study explored the perceptions of institutional personnel Á caregivers, staff members, supervisors, and administrators Á about organizational factors affecting their ability to care for orphaned and vulnerable children living in institutions in the Ashanti Region of Ghana. The participants in this study consisted of 59 caregivers, 7 supervisors, 10 administrators, 4 cooks, 4 teachers, 1 social worker, 1 security guard/driver, and 6 women classified as house helpers. Individual interviews were conducted using an English-written and stated semistructured interview guide the researchers had created. The data from the 92 interviews were transcribed and coded using inductive methodologies. The results revealed concerns from the personnel about their institutions' lack of adequate funding for essential items, including food and medicine for the children. The personnel were also concerned about the lack of appropriate workplace standards to ensure the sustainability of a viable workplace environment, including inadequate training, supervision, communication procedures, and staffing patterns, and collaborative partnerships and associations with other public or private community-based institutions. The findings from this study have considerable policy, practice, and research implications for social workers.