The aim of the present work was to develop a lain-human finite element model for cushion design to prevent bedsore by performing biomechanical analysis on interface pressure. The geometric data of the human was obtained by laser scans. The finite element model was composed of solid hexahedral elements. The material of the bed cushions was obtained according to the mechanical experiment. The human model was validated by comparing the simulation result with the experimental data. The validated finite element model could be used to facilitate, accelerate and economize the process of design of cushion.