Bedeutung der klonalen Hämatopoese für hämatologische Neoplasien

Götze, Katharina; Lengerke, Claudia

doi:10.1007/s00108-022-01401-0

Cited by 1 publication

(2 citation statements)

References 58 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Regarding the future management of people with CHIP, setting up 'CHIP clinics' is an important initiative. Here, individuals with certain risk factors for CHIP will be offered adequate screening, and individuals who are already diagnosed with CHIP will receive counseling and, if possible, a plan for intervention, considering individual lifestyle and environmental influences (178). For that purpose, ideally, hematologists and cardiologists should cooperate with hepatologists, geneticists, psychologists, and nutritionists in an interdisciplinary consultative clinic (178).…”

Section: Chip Detection and Risk Managementmentioning

confidence: 99%

“…Here, individuals with certain risk factors for CHIP will be offered adequate screening, and individuals who are already diagnosed with CHIP will receive counseling and, if possible, a plan for intervention, considering individual lifestyle and environmental influences (178). For that purpose, ideally, hematologists and cardiologists should cooperate with hepatologists, geneticists, psychologists, and nutritionists in an interdisciplinary consultative clinic (178). Comprehensive screening for CHIP mutations and identification of potential correlations with clinical patterns will facilitate consultation tailored to patients' individual needs and will also support further research into CHIP.…”

Section: Chip Detection and Risk Managementmentioning

confidence: 99%

See 1 more Smart Citation

Molecular and clinical aspects relevant for counseling individuals with clonal hematopoiesis of indeterminate potential

Cacic,

Schulz,

Germing

et al. 2023

Front. Oncol.

View full text Add to dashboard Cite

Clonal hematopoiesis of indeterminate potential (CHIP) has fascinated the medical community for some time. Discovered about a decade ago, this phenomenon links age-related alterations in hematopoiesis not only to the later development of hematological malignancies but also to an increased risk of early-onset cardiovascular disease and some other disorders. CHIP is detected in the blood and is characterized by clonally expanded somatic mutations in cancer-associated genes, predisposing to the development of hematologic neoplasms such as MDS and AML. CHIP-associated mutations often involve DNA damage repair genes and are frequently observed following prior cytotoxic cancer therapy. Genetic predisposition seems to be a contributing factor. It came as a surprise that CHIP significantly elevates the risk of myocardial infarction and stroke, and also contributes to heart failure and pulmonary hypertension. Meanwhile, evidence of mutant clonal macrophages in vessel walls and organ parenchyma helps to explain the pathophysiology. Besides aging, there are some risk factors promoting the appearance of CHIP, such as smoking, chronic inflammation, chronic sleep deprivation, and high birth weight. This article describes fundamental aspects of CHIP and explains its association with hematologic malignancies, cardiovascular disorders, and other medical conditions, while also exploring potential progress in the clinical management of affected individuals. While it is important to diagnose conditions that can lead to adverse, but potentially preventable, effects, it is equally important not to stress patients by confronting them with disconcerting findings that cannot be remedied. Individuals with diagnosed or suspected CHIP should receive counseling in a specialized outpatient clinic, where professionals from relevant medical specialties may help them to avoid the development of CHIP-related health problems. Unfortunately, useful treatments and clinical guidelines for managing CHIP are still largely lacking. However, there are some promising approaches regarding the management of cardiovascular disease risk. In the future, strategies aimed at restoration of gene function or inhibition of inflammatory mediators may become an option.

show abstract

Section: Chip Detection and Risk Managementmentioning

confidence: 99%

Section: Chip Detection and Risk Managementmentioning

confidence: 99%