2021
DOI: 10.1038/s41598-021-03922-4
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Bedside determination of microcirculatory oxygen delivery and uptake: a prospective observational clinical study for proof of principle

Abstract: Assessment of microcirculatory functional capacity is considered to be of prime importance for therapy guidance and outcome prediction in critically ill intensive care patients. Here, we show determination of skin microcirculatory oxygen delivery and consumption rates to be a feasible approach at the patient’s bedside. Real time laser-doppler flowmetry (LDF) and white light spectrophotometry (WLS) were used for assessment of thenar skin microperfusion, regional Hb and postcapillary venous oxygen saturation bef… Show more

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“…Unless the microvascular architecture is intact you cannot be certain that you are adequately resuscitating the patient and shock may continue to worsen. Other clinical variables such as haematocrit, pO2 or SvO2 would be needed to calculate the microcirculatory oxygen delivery [69]. The microcirculation is highly variable and subject to change in multiple acute injuries, such as trauma and post-cardiac bypass [70,71].…”
Section: Other Potential Sources Of Biasmentioning
confidence: 99%
“…Unless the microvascular architecture is intact you cannot be certain that you are adequately resuscitating the patient and shock may continue to worsen. Other clinical variables such as haematocrit, pO2 or SvO2 would be needed to calculate the microcirculatory oxygen delivery [69]. The microcirculation is highly variable and subject to change in multiple acute injuries, such as trauma and post-cardiac bypass [70,71].…”
Section: Other Potential Sources Of Biasmentioning
confidence: 99%