2021
DOI: 10.1038/s41577-021-00650-8
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‘Bedside’ observations challenge aspects of the ‘epithelial barrier hypothesis’

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Cited by 8 publications
(29 citation statements)
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“…One consequence is a lack of attention to roles of biologically active, plasma-derived molecules in early mucosal defense. Yet, in environmentally challenged airways, perhaps particularly in asthmatic bronchi ( 5 ), swift microvascular-epithelial transmission of nonsieved plasma peptides/proteins contributes prompt antimicrobial opportunities ( 6 , 7 ).…”
Section: Lack Of Attention To Physiology Of Endothelial-epithelial Ba...mentioning
confidence: 99%
See 4 more Smart Citations
“…One consequence is a lack of attention to roles of biologically active, plasma-derived molecules in early mucosal defense. Yet, in environmentally challenged airways, perhaps particularly in asthmatic bronchi ( 5 ), swift microvascular-epithelial transmission of nonsieved plasma peptides/proteins contributes prompt antimicrobial opportunities ( 6 , 7 ).…”
Section: Lack Of Attention To Physiology Of Endothelial-epithelial Ba...mentioning
confidence: 99%
“…At the primary site of respiratory infections, the human conducting airways ( 8 ), nonsieved plasma-derived macromolecules are transmitted across an intact epithelial lining without impeding the normal airway barrier against cenvironmental challenges ( 5 7 ). This direction-dependent asymmetry is a crucial, but overlooked ( 7 ), operational feature of the airway pseudostratified epithelial lining. Bedside and in vivo data suggest that exudation of plasma-derived peptides/proteins at the airway level has capacity to reduce progression of COVID-19 into severe pulmonary stages and beyond.…”
Section: Lack Of Attention To Physiology Of Endothelial-epithelial Ba...mentioning
confidence: 99%
See 3 more Smart Citations