Bee sting: The chemistry of an insect venom

O’Connor, Rod; Peck, Larry

doi:10.1021/ed057p206

Cited by 4 publications

(3 citation statements)

References 6 publications

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“…Hyaluronidase, the third most important component in bee venom (after melittin and phospholipase A 2 ) [ 27 ] was also fully inhibited by antivenom that was not harmful even when administered undiluted ( Figure 4A ). Honeybee antivenoms previously reported [ 11 , 12 ] were not tested against hyaluronidase, the second most abundant enzyme in the venom.…”

Section: Resultsmentioning

confidence: 99%

Production of the First Effective Hyperimmune Equine Serum Antivenom against Africanized Bees

et al. 2013

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Victims of massive bee attacks become extremely ill, presenting symptoms ranging from dizziness and headache to acute renal failure and multiple organ failure that can lead to death. Previous attempts to develop specific antivenom to treat these victims have been unsuccessful. We herein report a F(ab)´2-based antivenom raised in horse as a potential new treatment for victims of multiple bee stings. The final product contains high specific IgG titers and is effective in neutralizing toxic effects, such as hemolysis, cytotoxicity and myotoxicity. The assessment of neutralization was revised and hemolysis, the primary toxic effect of these stings, was fully neutralized in vivo for the first time.

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Section: Resultsmentioning

confidence: 99%

Production of the First Effective Hyperimmune Equine Serum Antivenom against Africanized Bees

et al. 2013

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“…More information on Purcell’s research is available online . Educators interested in this research may want to use a published experiment in which students analyze snake venom by electrophoresis , or incorporate the chemistry of bee stings into their lecture . Research Advances has previously reported on a new method for identifying compounds in spider venom without the isolation of individual compounds .…”

Section: The Secret Behind the Cone Snail’s Venom Pumpmentioning

confidence: 99%

Research Advances: Improving Our Understanding of Health Benefits and Dangers Associated with Nature’s Chemical Cupboard

King

2011

J. Chem. Educ.

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“…The composition of bee venom was investigated at the end of the 19 th century C.E., and it was wrongly concluded that formic acid was the main component. [5] In addition to water, bee venom contains proteins, polypeptides, amino acids, phospholipids, sugars, and volatile compounds including pheromones. Melittin comprises 40-60% of dry honey bee venom and is largely responsible for triggering a series of events which leads to the pain of a bee sting.…”

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confidence: 99%