Bee Venom Acupuncture for Musculoskeletal Pain: A Review

Lee, Myeong Soo; Pittler, Max H; Shin, Byung‐Cheul; Kong, Jae Cheol; Ernst, Edzard

doi:10.1016/j.jpain.2007.11.012

Cited by 99 publications

(87 citation statements)

References 33 publications

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“…As venoms of other species, BV has been known as a powerful anti-inflammatory agent (Lee 2002;Lee et al 2004Lee et al , 2008Kang et al 2002), an effective drug that has been used for centuries (in low doses-for shorter or longer treatments) to ameliorate or cure certain ailments, mainly arthritic and rheumatoid conditions and chronic pain (Banks and Shipolini 1986;Beck 1935;Broadman 1997;Forestier and Palmer 1984;Klinghardt 1990;Kwon et al 2002;Park et al 2004;Schmidt 1995;Son et al 2007); it has been also used in the treatment of hypersensitivity in allergic patients (Bousquet et al 1998;Forster and Urbanek 1979;Graft 1996;Müller 1979;Sicherer and Leung 2009). The research based on this natural product continues to find alternatives to classic therapy methods (e.g., for different types of cancer-Huh et al 2010; Ip et al 2008a, b;Pan et al 2010;Soman et al 2009;Tu et al 2008).…”

Section: Introductionmentioning

confidence: 99%

Electrophysiological and Structural Aspects in the Frontal Cortex After the Bee (Apis mellifera) Venom Experimental Treatment

Florea

Puica²,

Vintan

et al. 2011

Cell Mol Neurobiol

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The aim of this study is to evaluate the bioelectrical and structural-functional changes in frontal cortex after the bee venom (BV) experimental treatments simulating both an acute envenomation and a subchronic BV therapy. Wistar rats were subcutaneously injected once with three different BV doses: 700 μg/kg (T(1) group), 2100 μg/kg (T(3) group), and 62 mg/kg (sublethal dose-in T(SL) group), and repeated for 30 days with the lowest dose (700 μg/kg-in T(S) group). BV effects were assessed by electrophysiological, histological, histochemical, and ultrastructural methods. Single BV doses produced discharges of negative and biphasic sharp waves, and epileptiform spike-wave complexes. The increasing frequency of these elements suggested a dose-dependent neuronal hyperexcitation or irritation. As compared to the lower doses, the sublethal dose was responsible for a pronounced toxic effect, confirmed by ultrastructural data in both neurons and glial cells that underwent extensive, irreversible changes, triggering the cellular death. Subchronic BV treatment in T(S) group resulted in a slower frequency and increased amplitude of cortical activity suggesting neuronal loss. However, neurons were still stimulated by the last BV dose. Structural-functional data showed a reduced cellular density in frontal cortex of animals in this group, while the remaining neurons displayed both specific (stimulation of neuronal activity) and unspecific modifications (moderate alterations to necrotic phenomena). Molecular mechanisms involved in BV interactions with the nervous tissue are also discussed. We consider all these data very important for clinicians who manage patients with multiple bee stings, or who intend to set an appropriate BV therapy.

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Section: Introductionmentioning

confidence: 99%

Electrophysiological and Structural Aspects in the Frontal Cortex After the Bee (Apis mellifera) Venom Experimental Treatment

Florea

Puica²,

Vintan

et al. 2011

Cell Mol Neurobiol

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“…It has been reported to have a marked effect on a variety of ailments, such as arthritis, rheumatism, cancerous tumors, pain, angiocardiopathy, multiple sclerosis, and skin diseases (Kwon et al, 2002;Kim et al, 2003;Park et al, 2004;Russel et al, 2004;Kwon et al, 2005;Putz et al, 2006;Son et al, 2007;Lee et al, 2008). Honeybee venom is collected by an electric shock instrument, sometimes coupled with stimulating the honeybee to sting the surface of the collector sheet or venom is extracted from bee glands or sticks (Rybak et al, 1995;Rybak and Skubida, 2007).…”

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confidence: 99%

Qualitative and quantitative evaluation of melittin in honeybee venom and drug products containing honeybee venom

Haghi¹,

Hatami²,

Mehran³

2013

Journal of Apicultural Science

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a b s t r a c t a reverse-phase high-performance liquid chromatographic (rp-hplc) method was developed and validated for the analysis of honeybee venom samples and drug products containing honeybee venom. the validation parameters were linearity, sensitivity, precision, and recovery. melittin is the main component of honeybee venom was extracted with pure water, and then evaluated by rp-hplc with a photodiode array (pda) detector. separation of the samples was achieved on a europa protein c 18 column with linear gradient elution of acetonitrile and 0.4% phosphoric acid at 25°c. there was a flow rate of 1 ml/min. detection was set at 220 nm. limits of detection (lod) and quantification (loQ) for melittin were 1.1 and 3.2 µg/ml, respectively. the amount of melittin in honeybee venom samples ranged from 21.9 to 66.4 %.

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“…Acupuncture harmonizes the Qi and blood so as to restore the equilibrium of yin and yang (18). Acupuncture can be used in arthritis, pain, and rheumatoid diseases (20). All the studies suggested that acupuncture was effective in the short-term relief of the LE pain (18).…”

Section: Discussionmentioning

confidence: 99%

Acupuncture for Lateral Epicondylitis

Uğurlu¹,

Mollahaliloğlu²,

Nazlıkul³

2016

Med J Islamic World Acad Sci

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Lateral epicondylitis (LE), is one of the most common diseases of the arm with repetitive microtrauma by overuse of the wrist. Several conventional therapies are offered for tennis elbow.When classical conservative treatments are unsuccessful or have side effects, patients opt for complementary medicine, particularly needle acupuncture. A 26-year-old male right-handed amateur volleyball player presented with severe pain radiating from the lateral aspect of the right elbow. Pain was initiated by resisted wrist extension with the elbow in full extension and the forearm in pronation. His pain was unresponsive to NSAID, local corticosteroid injection, and 21 times rehabilitation. The body points were selected according to the pulse test in Chinese medicine, and the ear points were determined by detecting the Nogiers' ear acupuncture points. The energy level of the patient was measured using the pulse oscillography. Blocking was observed in all three energy circles on the pulse oscillography. At the end of the therapy, the average grip strength of the affected hand increased and VAS had decreased by the end of the treatment. The pulse oscillography indicated that the blocking and energy imbalance in the three circles were completely dissolved.In conclusion, acupuncture is an effective therapy for LE, and pulse oscillography is an important device for the diagnosis and therapy.

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Bee Venom Acupuncture for Musculoskeletal Pain: A Review

Cited by 99 publications

References 33 publications

Electrophysiological and Structural Aspects in the Frontal Cortex After the Bee (Apis mellifera) Venom Experimental Treatment

Electrophysiological and Structural Aspects in the Frontal Cortex After the Bee (Apis mellifera) Venom Experimental Treatment

Qualitative and quantitative evaluation of melittin in honeybee venom and drug products containing honeybee venom

Acupuncture for Lateral Epicondylitis

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