2010
DOI: 10.1007/s00063-010-1150-3
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Beeinträchtigung des kardialen autonomen Nervensystems und Arrhythmie-Inzidenz bei schwerer Hyperglykämie

Abstract: Clinical complications in high glucose levels must be seen in the context of a nearly complete blockade of sympathetic and parasympathetic activity. Basically to extreme autonomic restriction, sympathetic and vagal predominance can change rapidly into each other. This retarded vulnerable predisposition may declare the arrhythmic potential. An important progress in the monitoring of patients could be achieved by implementation of a continuous HRV measurement because hereby the actual risk potential can be ascer… Show more

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Cited by 8 publications
(4 citation statements)
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References 86 publications
(83 reference statements)
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“…Beyond electrolyte abnormalities and acidosis from increased serum ketones, other factors have also been implicated in the development of arrhythmias. During observation, Sufke et al ( 16 ) witnessed supraventricular and ventricular arrhythmias in 12 patients (10 with DKA and 2 with hyperglycemic hyperosmolar syndrome). Autonomic dysfunction resulting from high glucose levels was elucidated to be the cause of these arrhythmias ( 16 ).…”
Section: Commentarymentioning
confidence: 99%
“…Beyond electrolyte abnormalities and acidosis from increased serum ketones, other factors have also been implicated in the development of arrhythmias. During observation, Sufke et al ( 16 ) witnessed supraventricular and ventricular arrhythmias in 12 patients (10 with DKA and 2 with hyperglycemic hyperosmolar syndrome). Autonomic dysfunction resulting from high glucose levels was elucidated to be the cause of these arrhythmias ( 16 ).…”
Section: Commentarymentioning
confidence: 99%
“…Previous literature has reported that the deterioration of the cardiac autonomic nervous system in patients with diabetes is associated with an increase in cardiac and arrhythmogenic mortality. 20 Emerging evidence has also demonstrated that diabetes affects the electrical conduction system of the heart, culminating in lethal arrhythmia and sudden cardiac death. Hypoglycemia, hyperglycemia, and glucose uctuations can induce arrhythmia by activating various pathways 21,22 .…”
Section: Discussionmentioning
confidence: 99%
“…A total of 309 pregnant women were recruited in this study involving 280 patients, 29 of whom experienced two pregnancies during the 10 years, with an average age of 30.7 ± 4.5 years (range: 17-43 years). In the 309 cases with pre-excitation syndrome during pregnancy, 62 (20…”
Section: Patient Characteristicsmentioning
confidence: 99%
“…[ 95 ] In humans or animals with severe hyperglycemia, impairment of the cardiac autonomic nervous system may occur. [ 96 97 ] Diabetic gastroparesis is well-known but poorly understood phenomenon, which may also be due to affection of the autonomic innervation by the vagal nerve. [ 98 ]…”
Section: Disorders Of Lower Cranial Nervesmentioning
confidence: 99%