Background/Objectives: The relation between lifetime use of alcohol and measures of abdominal and general adiposity is unknown. Subjects/Methods: Among 99 381 men and 158 796 women of the European Prospective Investigation into Cancer and Nutrition (EPIC) study, means of waist circumference (WC), waist-to-hip-ratio (WHR) and body mass index (BMI), and odds ratios (OR) for a larger WC than predicted for a given BMI (WClp ¼ positive residuals of gender specific linear regression of BMI on WC) across categories of average lifetime use of alcohol (total, from wine and from beer) were calculated, all adjusted for socio-demographic, lifestyle and health factors. 1.32, 1.49) in men using 460 g/d and 1.63 (1.54, 1.73) in women using 424 g/d), though increase was higher for alcohol from beer than from wine (P for difference between beer and wineo0.001 (men) and ¼ 0.002 (women)). Conclusion: Lifetime alcohol use is positively related to abdominal and general adiposity in men, possibly following the male weight gain pattern; in women, it is positively related only to abdominal adiposity. In this context, beer may contribute additionally to abdominal adiposity.