Beer promotes differentiation and mineralization of human osteoblastic cells: Role of silicon

Millucci, Lia; Minetti, Mariagiulia; Orlandini, Maurizio; Braconi, Daniela; Schiavone, Maria Lucia; Galderisi, Silvia; Marzocchi, Barbara; Spiga, Ottavia; Rappuoli, R.; Spreafico, Adriano; Perretti, Giuseppe; Bernardini, Giulia; Santucci, Annalisa

doi:10.1016/j.jff.2019.01.023

Cited by 4 publications

(1 citation statement)

References 38 publications

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“…However, our biomeralization data exhibited a stronger promoting effect of BG scaffolds extracts on the ADSCs mineralization. These may be due to the 45S5 bioglass which is composed of 45% SiO 2 , 24.5% Na 2 O, 24.5% CaO, and 6% P 2 O 5 , and the dissolution from 45S5 bioglass such as Ca, P and Si were favorable to extracellular matrix mineralization, calcification of bone tissue and increases bone mineral density [ [42] , [43] ]. XLS (Na + 0.7 [(Si 8 Mg 5.5 Li 0.3 )O 20 (OH) 4 ] − 0.7 ) is a disk-shaped crystal with a diameter around 25 nm and a height around 1 nm [ 27 ].…”

Section: Resultsmentioning

confidence: 99%

Hypoxia-mimicking 3D bioglass-nanoclay scaffolds promote endogenous bone regeneration

Zheng

Zhang

Wang

et al. 2021

Bioactive Materials

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Large bone defect repair requires biomaterials that promote angiogenesis and osteogenesis. In present work, a nanoclay (Laponite, XLS)-functionalized 3D bioglass (BG) scaffold with hypoxia mimicking property was prepared by foam replication coupled with UV photopolymerization methods. Our data revealed that the incorporation of XLS can significantly promote the mechanical property of the scaffold and the osteogenic differentiation of human adipose mesenchymal stem cells (ADSCs) compared to the properties of the neat BG scaffold. Desferoxamine, a hypoxia mimicking agent, encourages bone regeneration via activating hypoxia-inducible factor-1 alpha (HIF-1α)-mediated angiogenesis. GelMA-DFO immobilization onto BG-XLS scaffold achieved sustained DFO release and inhibited DFO degradation. Furthermore, in vitro data demonstrated increased HIF-1α and vascular endothelial growth factor (VEGF) expressions on human adipose mesenchymal stem cells (ADSCs). Moreover, BG-XLS/GelMA-DFO scaffolds also significantly promoted the osteogenic differentiation of ADSCs. Most importantly, our in vivo data indicated BG-XLS/GelMA-DFO scaffolds strongly increased bone healing in a critical-sized mouse cranial bone defect model. Therefore, we developed a novel BG-XLS/GelMA-DFO scaffold which can not only induce the expression of VEGF, but also promote osteogenic differentiation of ADSCs to promote endogenous bone regeneration.

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Section: Resultsmentioning

confidence: 99%