Beginner's luck – the first <i>in vivo</i> demonstration of functioning platelets; William Duke, 1910

Boulton, Frank

doi:10.1111/j.1365-3148.2011.01126.x

Cited by 3 publications

(1 citation statement)

References 18 publications

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“…As well as the awkward propensity of shed blood to clot, the main problems included the unpredictable and apparently random adverse reactions which could be fatal (Boulton, ). Nevertheless, many transfusions were conducted in urgent circumstances such as trauma (accidental or surgical); haemorrhages (such as post‐partum); or in conditions such as haemophilia or thrombocytopenia (Roussel, ; Duke, ; Boulton, ), facilitated by direct donor to recipient transfusion; and severe ‘pernicious’ anaemia in one series of which phosphate anticoagulation was used (Brakenridge, ; Boulton, ).…”

Section: To Bleed or Not To Bleed Or Whether It Is Better To Transfusmentioning

confidence: 99%

Blood transfusion at the time of the First World War – practice and promise at the birth of transfusion medicine

Boulton

Roberts

2014

Transfusion Medicine

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The centenary of the start of the First World War has stirred considerable interest in the political, social, military and human factors of the time and how they interacted to produce and sustain the material and human destruction in the 4 years of the war and beyond. Medical practice may appear distant and static and perhaps seems to have been somewhat ineffectual in the face of so much trauma and in the light of the enormous advances in medicine and surgery over the last century. However, this is an illusion of time and of course medical, surgical and psychiatric knowledge and procedures were developing rapidly at the time and the war years accelerated implementation of many important advances. Transfusion practice lay at the heart of resuscitation, and although direct transfusion from donor to recipient was still used, Geoffrey Keynes from Britain, Oswald Robertson from America and his namesake Lawrence Bruce Robertson from Canada, developed methods for indirect transfusion from donor to recipient by storing blood in bottles and also blood-banking that laid the foundation of modern transfusion medicine. This review explores the historical setting behind the development of blood transfusion up to the start of the First World War and on how they progressed during the war and afterwards. A fresh look may renew interest in how a novel medical speciality responded to the needs of war and of post-war society.

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Section: To Bleed or Not To Bleed Or Whether It Is Better To Transfusmentioning

confidence: 99%

Blood transfusion at the time of the First World War – practice and promise at the birth of transfusion medicine

Boulton

Roberts

2014

Transfusion Medicine

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Platelets: Frozen and Freeze-Dried Current Products in Development and Regulatory Licensing Challenges

Pidcoke¹,

Kelly

Fitzpatrick³

et al. 2019

Damage Control Resuscitation

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Effect of plateletpheresis on donor variables and platelet yield using three different cell separators: Experience from tertiary care hospital

Sharma¹,

Bundas²,

Prinja³

et al. 2022

Asian Journal of Transfusion Science

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INTRODUCTION: Platelet collection by apheresis is common nowadays. Many cell separators are available in the market for the same. This study was conducted to study the effect of various donor factors on platelet yield and the effect of different cell separator variables on platelet yield. MATERIALS AND METHODS: This cross-sectional study was done on 600 healthy apheresis platelet donors from April 2016 to March 2017 using three different cell separators. Donor variables, pre, and post-plateletpheresis hematological parameters, machine variables, platelet yield were observed. RESULTS: Postprocedural decline in hematological variables was seen. A positive correlation was seen with pre-apheresis platelet count, blood volume processed, and product volume. Product volume obtained was highest with COM. TEC. Mean platelet yield was maximally seen in Amicus. CONCLUSION: Main predictors of platelet yield are platelet count and volume processed. Donors with lower hemoglobin had better yields. Higher platelet counts lead to better product hence platelet increment in the patient.

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Beginner's luck – the first in vivo demonstration of functioning platelets; William Duke, 1910

Cited by 3 publications

References 18 publications

Blood transfusion at the time of the First World War – practice and promise at the birth of transfusion medicine

Blood transfusion at the time of the First World War – practice and promise at the birth of transfusion medicine

Platelets: Frozen and Freeze-Dried Current Products in Development and Regulatory Licensing Challenges

Effect of plateletpheresis on donor variables and platelet yield using three different cell separators: Experience from tertiary care hospital

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