If there is something that can be defined as the "Sisyphus' rock of human sciences that would be the wide array of circumstances, interpretations and processes generated by human beings and their numberless organizations, with regard to groups, communities, collectives, languages… "Cultures". Thus, when (pre)historians have the chance to resort to hard sciences, they cling tightly to it, sometimes even with a blind trust, in the hope of finding a reference point for their intrinsically human-and therefore multidimensional and multifocalinterpretations, open to different possible solutions. In recent years the study of the past has placed its trust in dating techniques,particularly in 14C-, in statistical analyses and in genetic studies, among other such possibilities, in a way that they could be considered as the new "guide fossils" in prehistorical research. For instance, the chronology of a domestic animal or plant would be taken as an undeniable marker of the "Neolithic" period, and something similar could be said of the hypothetical presence of a Near Eastern haplogroup in a VI millennium BC European individual. However, from a (pre)historic viewpoint, things are not so clear or so "hard". The present paper focuses on the analysis of the palaeogenetic data available for the Neolithisation process and the Early Neolithic period in the Iberian Peninsula. We have considered the information from a historical and anthropological perspective in an attempt to understand and complement the interpretations derived from the geneticists themselves. Moreover, a part of the paper is devoted to explain the archaeological consequences of the types of analysis carried out and the results of such studies. The final goal would be to broaden the possible interpretations of the Neolithisation process and the Early Neolithic period in this territory. 2) PALAEOGENETIC EVIDENCE OF THE MESOLITHIC-NEOLITHIC TRANSITION IN EUROPE Understanding the jargon commonly used in genetics can be challenging for an unfamiliar audience, this being probably the main cause of misinterpretation of genetic data by non-experts. With this in mind, the main concepts used in population genetic studies have been compiled in supplementary information and explained in a simple way, starting from the very basics (Supplementary Information 1). During the last few years we have witnessed an exponential increase in the quantity (and quality) of prehistoric human paleogenetic data. Two main factors have contributed to this fact, namely the development of a new genotyping technique-the so-called Next Generation Sequencing or NGS-and a new sampling strategy targeting the densest of the bones-the petrous