Beh�et's disease associated with myelodysplastic syndromes

Abstract

These data suggest that trisomy 8 predisposes to Behçet's disease in patients with MDS. Furthermore, an increased ROS production by neutrophils may be associated with the diverse clinical findings in this disease. In this study, neutrophils were activated directly by serum factors.

Successful Treatment of Myelodysplastic Syndrome (MDS)-related intestinal Behcet's Disease by Up-front Cord Blood Transplantation

“…Recently, it is also used as a new therapy for the treatment of severe autoimmune diseases such as multiple sclerosis, systemic sclerosis and systemic lupus erythematosus (13)(14)(15). Autologous HSCT has also been performed on three patients with Behçet's disease (16)(17)(18) (2,5,11,12 …”

“…Interestingly, it is speculated that this is not a simple coexistence but that the aetiology of intestinal Behçet's disease is at least partly derived from MDS itself (2,5,11,12 (4,6,9 CT s c a n s s h o we d ma r k e d e d e ma o f t h e i l e o c e c u m r e g i o n ( a r r o ws ) a n d i n f l a mma t i o n o f t h e s u r r o u n d i n g f a t t i s s u e . dup (1) …”

Massive Hemorrhage in a Patient with Intestinal Behçet's Disease: Report of a Case

“…[12][13][14] Our patient was found to have MDS with trisomy 8. This karyotypic change has been found in 78% of cases of MDS associated with Behçet's disease.…”

Retinal S-Antigen–Reactive Lymphocytes in a Patient with Uveitis Associated with Myelodysplastic Syndromes

“…l Thus, rheumatoid arthritis, systemic lupus erythematosus, and Behçet's disease have been reported in certain cases of MDS. 2 Ohno et at have reported 11 cases of Behçet's disease with MDS and only two of them exhibited anterior uveitis. 2 We describe a patient who developed bilateral uveitis during the course of MDS.…”

“…2 Ohno et at have reported 11 cases of Behçet's disease with MDS and only two of them exhibited anterior uveitis. 2 We describe a patient who developed bilateral uveitis during the course of MDS. Interestingly, we detected a strong proliferative response of the peripheral blood lymphocytes (PBLs) to S-Ag, which is a target antigen of autoimmune uveitis.…”